Integrative Pharmacological Sciences Training Program (IPSTP)

项目摘要/摘要 该综合药理学培训计划(IPSTP)旨在支持2年级和3年级 攻读药理学论文研究项目的博士生。受训人员和培训 教师来自7个博士项目(生物化学和分子生物学、化学、化学工程 和材料科学、微生物学和分子遗传学、神经科学、药理学和毒理学以及 生理学)。IPSTP的两个独特的重点领域是体内药理学培训 方法和药物发现。IPSTP培训人员的研究专长分为三类 重叠的主题：1)疾病的分子机制与新的治疗设计的交集；2) 内分泌和代谢紊乱与癌症和心血管过程的整合；以及，3) 系统生物学和生物信息学在了解药物机制和疾病中的应用。基金是 要求支持8名学生(或每年4名学生进入该计划)。培训计划将是 由一名计划主任(NeuBig)、两名副主任(Dorrance和Atchison)和一名 由项目代表组成的执行委员会。该计划还由一个 药理学博士项目和制药业专家外部咨询委员会 以及由学员组成的学生咨询委员会。培训计划有8个核心要素：1)a) 研究项目，其结果导致了博士论文和对知识的贡献 药理学；2)为期一周的药物发现和体内药理学强化课程；3) 药理学和生物统计学三门课程；4)专业两门课程 开发；5)参加定量系统生物学研讨会；6)每月交流技能 和专业发展论坛；7)参加年度项目务虚会；8)每月由学生管理 杂志俱乐部。学生将在直接学习期间参与最后三个要素。 T32支持和随后的所有年份，直到毕业。学员亦须参加 由研究生院和项目提供的负责任的研究行为(RCR)系列研讨会 具体的RCR活动。学员可参加的补充活动包括：1)教学机会；2) 参加国立卫生研究院资助的密歇根州立大学最佳项目，以及3)非学术领域的实地考察 事业。IPSTP已经制定了一项全面的计划来招收高素质的学生，包括以下学生- 代表少数族裔学生。IPSTP将为学员提供优秀的研究和专业知识 培训，并将为他们在学术界、工业界和政府的研究生涯做好准备。

Project Summary / Abstract This Integrative Pharmacological Sciences Training Program (IPSTP) is designed to support 2nd and 3rd year Ph.D. students pursuing dissertation research projects in the pharmacological sciences. Trainees and training faculty are drawn from 7 Ph.D. programs (Biochemistry & Molecular Biology, Chemistry, Chemical Engineering and Materials Science, Microbiology & Molecular Genetics, Neuroscience, Pharmacology & Toxicology and Physiology). The two areas of unique focus within the IPSTP are training on in vivo pharmacological approaches and drug discovery. The research expertise of IPSTP training faculty is clustered into three overlapping themes: 1) the intersection of molecular mechanisms of disease with novel therapeutic design; 2) integration of endocrine and metabolic derangements with cancer and cardiovascular processes; and, 3) application of systems biology and bioinformatics to understand drug mechanisms and disease. Funds are requested to support 8 students (or 4 students entering the program per year). The training program will be administered by a Program Director (Neubig), two Associate Directors (Dorrance and Atchison) and an Executive Committee composed of representatives from the programs. The program is also guided by an External Advisory Committee of experts from Pharmacology Ph.D. programs and the pharmaceutical industry and a Student Advisory Committee composed of trainees. There are 8 core elements to the training plan: 1) a research project whose results lead to a Ph.D. dissertation and a contribution to knowledge in the pharmacological sciences; 2) two week-long intensive courses in drug discovery and in vivo pharmacology; 3) a three course curriculum in pharmacology and biostatistics; 4) a two course curriculum in professional development; 5) participation in a quantitative systems biology workshop; 6) a monthly Communications Skills and Professional Development Forum; 7) participation in an annual program retreat; 8) a monthly student-run journal club. Students will be expected to participate in the last three elements for the duration of their direct T32 support and for all subsequent years until graduation. Trainees are also required to attend the Responsible Conduct of Research (RCR) workshop series provided by the Graduate School and program specific RCR activities. Supplemental activities available to trainees include: 1) teaching opportunities; 2) participation in the NIH-funded MSU BEST program, and 3) field-trips to regional sites for non-academic careers. The IPSTP has developed a comprehensive plan to recruit highly qualified students including under- represented minority students. The IPSTP will provide trainees with excellent research and professional training and will prepare them for research careers in academia, industry and government.