INTEGRATIVE IMAGING INFORMATICS FOR CANCER RESEARCH

 描述(申请人提供)：非侵入性成像程序的发展，为预后和早期治疗反应提供替代标记，有可能提高临床医生有效治疗肿瘤患者的能力。然而，由于缺乏足够的信息学技术，将先进的成像技术纳入肿瘤学研究环境的速度一直很慢。癌症研究综合成像信息学(I3CR)计划将通过开发两个信息学平台来解决这一差距。I3CR数据管理平台将作为一个信息学中心，整合图像采集、分析工作流程、表型和基因组数据源以及临床信息和治疗系统。数据管理平台将被开发为XNAT成像信息学系统的主要新扩展，以包括其他特定于癌症的数据类型、新的网络服务、对多种广泛使用的数据格式的支持以及定制的用户界面组件。此外，I3CR将与多家外部技术提供商合作，将数据管理平台与广泛使用的可视化和分析应用程序、补充数据库系统以及临床诊断和治疗系统整合在一起。I3CR知识管理平台将使研究人员能够发布文件夹，记录和跟踪源数据、派生数据、软件应用程序和脚本以及用于产生科学发现的计算资源。知识管理平台将与广泛使用的工作流程引擎和数据管理平台无缝集成，以生成可直接与出版物捆绑在一起的知识组合，以实现可重复的研究。I3CR计划的中心假设是，综合信息学技术将使癌症研究人员能够克服目前阻碍科学进步的技术障碍。我们将在癌症成像研究人员的联合网络的背景下评估这一假设，其中包括NCI定量成像网络的成员，该网络将在放射治疗剂量优化和胶质母细胞瘤肿瘤图谱方面开展试点项目。所有软件都将是开放源码的，并通过若干外联渠道得到支持，包括年度技术讲习班、每月电话会议和活跃的网上讨论论坛。

 DESCRIPTION (provided by applicant): The development of non-­invasive imaging procedures that provide surrogate markers for prognosis and early response to therapy has the potential to improve clinicians' ability to effectively treat patients with oncologic disease. However, the incorporation of advanced imaging into oncology research settings has been slowed by a lack of adequate informatics technology. The Integrative Imaging Informatics for Cancer Research (I3CR) program will address this gap informatics technology by developing two informatics platforms. The I3CR Data Management Platform will serve as an informatics hub that integrates image acquisition, analysis workflows, phenotypic and genomic data sources, and clinical information and treatment systems. The Data Management Platform will be developed as a major new extension of the XNAT imaging informatics system to include additional cancer-­specific data types, new web services, support for a number of widely used data formats, and customized user interface components. In addition, I3CR will collaborate with a number of external technology providers to integrate the Data Management Platform with widely used visualization and analysis applications, complementary database systems, and clinical diagnostic and treatment systems. The I3CR Knowledge Management Platform will enable researchers to publish portfolios that document and track the source data, derived data, software applications and scripts, and computing resources used to generate scientific findings. The Knowledge Management Platform will integrate seamlessly with widely used workflow engines and the Data Management Platform to generate knowledge portfolios that can be tied directly to publications to enable reproducible research. The central hypothesis of the I3CR program is that integrative informatics technology will enable cancer researchers to overcome technical hurdles that currently impede scientific progress. We will evaluate this hypothesis within the context of a federated network of cancer imaging researchers, including members of the NCI Quantitative Imaging Network that will undertake pilot projects in radiation therapy dose optimization and glioblastoma tumor mapping. All software will be open source and supported through a number of outreach channels, including annual technical workshops, monthly teleconferences, and an active web-­based discussion forum.