THE INFORMATICS, DATA ANALYSIS, AND STATISTICS CORE (IDASC)

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ABSTRACT FOR IDASC The Informatics, Data Analysis, and Statistics Core (IDASC) will implement the Human Connectome Project’s data analysis approach for the Aging Adult Brain Connectome (AABC) Project’s multi-modal imaging data. It will archive the imaging data as it is collected by the Integrated Data Acquisition Core (IDAC) and provide feedback to the IDAC on any data quality concerns as a part of its initial quality control. The IDASC will also curate and manage biological, sociological, and behavioral measures from the Genetics and Multi-omics Specimens Core (GMSC) and IDAC. The HCP’s brain imaging preprocessing pipelines will be run on the imaging data when it has been accepted by the database. This includes preprocessing for structural, functional, diffusion, and ASL MRI data. The IDASC will then perform quality control on these preprocessing results. The IDASC will also develop cross-sectional and longitudinal data analysis pipelines to generate multi-modal Imaging Data Phenotypes (IDPs) representing brain architectural/morphometric, functional, and connectivity measures at the levels of brain areas, functional networks, and white matter tracts. Using these imaging measures together with the biological, sociological, and behavioral measures collected and generated by the IDAC and GMSC, the IDASC will assist the 4 sub-projects with generation of optimized longitudinal statistical models to address their specific hypotheses about interactions between brain, behavior/sociological, and biological factors that contribute to Alzheimer’s Disease (AD) or other dementias. The IDASC will also share data at the conclusion of the project.