THE INFORMATICS, DATA ANALYSIS, AND STATISTICS CORE (IDASC)

IDASC摘要 信息学、数据分析和统计核心(IDASC)将实施人类连接项目的 AABC计划多模式成像数据的数据分析方法。会的 将综合数据采集核心(IDAC)收集的成像数据存档并提供反馈 向国际数据中心报告任何数据质量问题，作为其初始质量控制的一部分。IDASC还将主持和 从遗传学和多组学样本核心管理生物学、社会学和行为测量 (GMSC)和IDAC。HCP的脑成像前处理流水线将在成像数据上运行 已被数据库接受。这包括对结构、功能、扩散和ASL的预处理 核磁共振数据。然后，IDASC将对这些预处理结果进行质量控制。IDASC还将 开发横断面和纵向数据分析管道，以生成多模式成像数据 表示大脑结构/形态测量、功能和连通性测量的表型(IDP) 脑区、功能网络和白质束的水平。将这些成像措施与 IDAC和GMSC收集和产生的生物、社会和行为衡量标准， IDASC将协助4个子项目生成优化的纵向统计模型，以解决其 关于大脑、行为/社会和生物因素之间相互作用的具体假设 导致阿尔茨海默病(AD)或其他痴呆症。IDASC还将在#年结束时共享数据 这个项目。

ABSTRACT FOR IDASC The Informatics, Data Analysis, and Statistics Core (IDASC) will implement the Human Connectome Project’s data analysis approach for the Aging Adult Brain Connectome (AABC) Project’s multi-modal imaging data. It will archive the imaging data as it is collected by the Integrated Data Acquisition Core (IDAC) and provide feedback to the IDAC on any data quality concerns as a part of its initial quality control. The IDASC will also curate and manage biological, sociological, and behavioral measures from the Genetics and Multi-omics Specimens Core (GMSC) and IDAC. The HCP’s brain imaging preprocessing pipelines will be run on the imaging data when it has been accepted by the database. This includes preprocessing for structural, functional, diffusion, and ASL MRI data. The IDASC will then perform quality control on these preprocessing results. The IDASC will also develop cross-sectional and longitudinal data analysis pipelines to generate multi-modal Imaging Data Phenotypes (IDPs) representing brain architectural/morphometric, functional, and connectivity measures at the levels of brain areas, functional networks, and white matter tracts. Using these imaging measures together with the biological, sociological, and behavioral measures collected and generated by the IDAC and GMSC, the IDASC will assist the 4 sub-projects with generation of optimized longitudinal statistical models to address their specific hypotheses about interactions between brain, behavior/sociological, and biological factors that contribute to Alzheimer’s Disease (AD) or other dementias. The IDASC will also share data at the conclusion of the project.