An Imaging Repository for the Cerebrovascular Disease Knowledge Portal (iCDKP)

项目摘要 中风是世界第二大死因。到2030年，全球估计将有1.224亿人 而仅在美国，与中风相关的医疗费用预计就将超过1800亿美元。此外， 中风本身只是脑血管疾病最急性的表现，脑血管疾病也会导致慢性 大脑功能进行性恶化，包括认知障碍和痴呆症的血管因素 (VCID)。尽管迫切需要新的治疗方法，但导致脑缺血的确切生物途径 出血，大脑对损伤的反应，以及大脑的恢复能力仍然很差 明白了。成像提供了这些过程的关键和可量化的测量。如果不成像，它就是 不可能描述受影响的大脑的位置、涉及的脑组织的数量或大脑的数量 肿胀/浮肿。此外，同一患者随时间的连续图像捕捉动态生理学，例如 梗塞增长或出血增长，这对研究损伤和恢复都是至关重要的。《国际邮报》 中风遗传学联合会(ISGC)的成立是为了利用人类遗传学来识别新的生物学 最终可能导致有效治疗中风的途径。事实上，候选药物治疗得到了支持 根据人类遗传学的证据，这些药物更有可能获得FDA的批准。ISGC的 对大型协调数据集、开放数据共享和协作文化的承诺导致了这一发现 到目前为止，所有得到有力支持的中风常见形式的风险基因中，有许多已经被 作为新治疗方法的基础进行了研究。2017年，ISGC推出了《脑血管疾病知识》 门户网站(CDKP)(R24NS092983)，以遵守的方式与研究社区自由共享基因数据 遵守公平数据原则。这种资源的一个主要限制是缺乏大脑图像。对于这项提议 生物医学数据仓库合作协议(U24)我们将聚合大脑成像和基因数据 根据公平数据原则，从大约30,000名中风患者中获得并分享这些数据 根据公平数据原则。建立卒中神经影像表型库的基础上 (SNIPR)，我们的计划将把CDKP转换为成像CDKP(ICDKP)， 为全球社区提供获得遗传、表型和成像数据的单一公平访问点。 里程碑驱动的AIMS将：1)聚合来自国际各地的高价值中风成像数据集 调查员社区；2)实施公平的数据共享做法和程序；3)参与研究 具有存储库的社区。我们的团队，由CDKP和SNIPR的PI领导，非常适合执行这个项目 鉴于我们在与国际中风研究界协商后制定了这项建议，以 确保获得广泛的支持，并最大限度地满足他们的预期需求。

PROJECT ABSTRACT Stroke is the world’s second-leading cause of death. By 2030 an estimated 122.4 million people world-wide will be affected while stroke-related medical costs in the US alone are projected to exceed $180 billion. Furthermore, stroke itself is only the most acute manifestation of cerebrovascular disease, which also causes chronic progressive deterioration in brain function, including vascular contributions to cognitive impairment and dementia (VCID). Despite a pressing need for novel treatments, the precise biological pathways that lead to brain ischemia and hemorrhage, the response of the brain to injury, and the brain’s capacity for recovery remain poorly understood. Imaging provides crucial and quantifiable measures of these processes. Without imaging it is impossible to characterize the location of the brain affected, quantity of brain tissue involved, or amount of brain swelling/edema. Furthermore, serial images of the same patient over time capture dynamic physiology such as infarct growth or hemorrhage growth, which are both crucial to studying injury and recovery. The International Stroke Genetics Consortium (ISGC) was founded to harness human genetics to identify novel biological pathways that can ultimately lead to effective treatments for stroke. Indeed, candidate drug treatments supported by evidence from human genetics are substantially more likely to achieve FDA approval. The ISGC’s commitment to large harmonized data sets, open data sharing and collaborative culture has led to the discovery of all of the robustly supported risk genes for common forms of stroke to date, many of which are already being studied as the basis for novel treatments. In 2017 the ISGC launched the Cerebrovascular Disease Knowledge Portal (CDKP) (R24NS092983) to share genetic data freely with the research community in a manner adherent to FAIR Data Principles. A major limitation of this resource is the absence of brain images. For this proposed biomedical data repository cooperative agreement (U24) we will aggregate brain imaging and genetic data according to FAIR data principles from an estimated 30,000 individuals with stroke and share these data according to FAIR data principles. Building on the established Stroke Neuro-Imaging Phenotype Repository (SNIPR) at Washington University, our program will transform the CDKP into the imaging CDKP (iCDKP), providing the global community with a single FAIR access point to genetic, phenotypic, and imaging data. Milestone-driven aims will: 1) Aggregate high value stroke imaging datasets from across the international investigator community; 2) Implement FAIR data sharing practices and procedures; 3) Engage the research community with repository. Our team, led by the PIs for CDKP and SNIPR is well-situated to execute this project given that we have developed this proposal in consultation with the international stroke research community to ensure broad support and maximum response to their anticipated needs.