Genetic and Physical Basis of Mechanical Neuroprotection
机械神经保护的遗传和物理基础
基本信息
- 批准号:9005894
- 负责人:
- 金额:$ 36.69万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-03-01 至 2020-02-29
- 项目状态:已结题
- 来源:
- 关键词:ActinsAcuteAffectAfferent NeuronsAnemiaAnimal ModelAnimalsAxonBehaviorBiochemicalBiochemistryBiological AssayBlood capillariesBrain DiseasesCaenorhabditis elegansCell membraneCellsCollaborationsConfocal MicroscopyCytoskeletonDefectDendritic SpinesDevelopmentDiseaseDissectionErythrocytesEsthesiaFluorescence Resonance Energy TransferFutureGene Transfer TechniquesGenesGeneticHeadHealthHumanImageIn VitroInjuryInvestigationIon ChannelJointsKnowledgeLabelLifeLinkLocationMammalsMeasuresMechanical StressMechanicsMechanoreceptorsModelingMolecularMorphologyMotor NeuronsMovementMuscleMutationNervous System PhysiologyNervous system structureNeuritesNeuronsNeurosciencesOrganismPainPhysiologyPredispositionProcessProprioceptionProtein IsoformsProteinsResearchRisk FactorsRoleSensorySignal TransductionSkinSpectrinSpeedStressStretchingSusceptibility GeneTestingTouch sensationTranscriptTransgenic AnimalsTransgenic OrganismsTranslatingTraumatic Brain InjuryWorkalpha Spectrinbasebeta SpectrinbetaIV spectrincapillarycell typedesigndigital imagingdimerexperienceflexibilityimage processingin vivoinsightmigrationmutantneglectneuroprotectionnovelpotential biomarkerreceptorrelating to nervous systemresilienceresponsesensorsomatosensorytooltrafficking
项目摘要
DESCRIPTION (provided by applicant): The development and function of the nervous system is regulated not only by electrical and biochemical signals, but also by mechanical inputs. For instance, most if not all neurons generate mechanical stress and experience strain during migration, axon outgrowth, and dendritic spine remodeling. With a few notable exceptions, however, the study of cell mechanics has been neglected in neuroscience. We seek to fill this knowledge gap by investigating the genetic and physical basis of how neurons withstand mechanical stress focusing on C. elegans touch receptor neurons as a model. Key entry points for this investigation are the findings that loss of unc-70 ß spectrin function makes C. elegans neurons vulnerable to damage induced by normal movement and the well-known function for actin-spectrin networks in protecting red blood cells from the mechanical strains generated as they transit through tiny capillaries. In new work, we establish a simple visible assay for loss of
spectrin function in the ventral touch receptor neurons and create transgenic animals expressing a genetically-encoded strain sensor that enables us to visualize how body bending and touch sensation affects stress in neural actin-spectrin networks. The proposed research combines genetic dissection, high-speed quantitative confocal microscopy, and in vitro biochemistry to investigate the role of spectrin networks in mechanical neuroprotection and sensory mechanoelectrical transduction. This work has the potential to transform understanding of neuronal cell mechanics and the contribution of actin-spectrin networks in this process. The new knowledge we seek to acquire could provide insight into the genetic basis of mechanical neuroprotection and potential risk factors related to traumatic brain injury.
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Miriam B Goodman其他文献
Miriam B Goodman的其他文献
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{{ truncateString('Miriam B Goodman', 18)}}的其他基金
The biophysics of skin-neuron sensory tactile organs and their sensitivity to mechanical and chemical stress
皮肤神经元感觉触觉器官的生物物理学及其对机械和化学应力的敏感性
- 批准号:
10176122 - 财政年份:2020
- 资助金额:
$ 36.69万 - 项目类别:
The biophysics of skin-neuron sensory tactile organs and their sensitivity to mechanical and chemical stress
皮肤神经元感觉触觉器官的生物物理学及其对机械和化学应力的敏感性
- 批准号:
10320377 - 财政年份:2017
- 资助金额:
$ 36.69万 - 项目类别:
The biophysics of skin-neuron sensory tactile organs and their sensitivity to mechanical and chemical stress
皮肤神经元感觉触觉器官的生物物理学及其对机械和化学应力的敏感性
- 批准号:
10633441 - 财政年份:2017
- 资助金额:
$ 36.69万 - 项目类别:
The biophysics of skin-neuron sensory tactile organs and their sensitivity to mechanical and chemical stress
皮肤神经元感觉触觉器官的生物物理学及其对机械和化学应力的敏感性
- 批准号:
10063587 - 财政年份:2017
- 资助金额:
$ 36.69万 - 项目类别:
The biophysics of skin-neuron sensory tactile organs and their sensitivity to mechanical and chemical stress
皮肤神经元感觉触觉器官的生物物理学及其对机械和化学应力的敏感性
- 批准号:
10534243 - 财政年份:2017
- 资助金额:
$ 36.69万 - 项目类别:
Genetic and Physical Basis of Mechanical Neuroprotection
机械神经保护的遗传和物理基础
- 批准号:
8858468 - 财政年份:2015
- 资助金额:
$ 36.69万 - 项目类别:
Temperature Sensation and Its Behavioral Consequences
温度感觉及其行为后果
- 批准号:
7491448 - 财政年份:2007
- 资助金额:
$ 36.69万 - 项目类别:
Temperature Sensation and Its Behavioral Consequences
温度感觉及其行为后果
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7360220 - 财政年份:2007
- 资助金额:
$ 36.69万 - 项目类别:
Force Clamp Systems for Evaluation of Mechanotransduction
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8244400 - 财政年份:2007
- 资助金额:
$ 36.69万 - 项目类别:
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