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400 MHz NMR Spectrometer for CSU Central Instrument Facility

适用于科罗拉多州立大学中央仪器设施的 400 MHz 核磁共振波谱仪

基本信息

批准号：
9076089
负责人：
Christopher D Rithner
金额：
$ 51.66万
依托单位：
COLORADO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-04-15 至 2018-03-14
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): The Chemistry Department at Colorado State University is requesting funds to purchase a new 400 MHz NMR spectrometer that will replace an eighteen year old Varian 300 MHz NMR with a Mercury-Plus console. The instrument will be managed within the Central Instrument Facility (CIF) that is a Colorado State University Foundational Core homed in the Department of Chemistry. The instrument will be in a brand new CORE laboratory that is part of the New Chemistry building that is under construction. At the present time, we do the greatest portion of our NMR work on four Varian NMR instruments with proton frequencies ranging from 300 to 500 MHz. One of these - the subject of this proposal- needs to be replaced. This 7.2 Tesla, 300 MHz NMR magnet is not shielded, console electronics are past their prime and failing, are comparatively noisy, functionally limited and challenging to repair or replace. Probes are worn out, have comparatively poor performance and are, frankly, fragile antiques. Despite this, the 300 NMR is still relied on for routine NMR studies in a self-service, walk-up mode. In contrast, the proposed 400 NMR will support full automation, be equipped with a sample changer, an automated high performance room temperature" probe and a liquid nitrogen-cooled cold-probe. The magnet solenoid will be actively shielded and have a long hold helium Dewar that will be advantageous when coupled with our new, internally funded helium liquefying project. This combination of magnet field control, console technology, cold probe, sample changer and advanced software provides significantly better sensitivity, resolution and performance compared with the NMR that it replaces. Indeed, the NMR performance is sufficiently good that\ we expect to do some kinds of NMR, e.g. 13C and fast 2D, on this new 400 NMR rather than on the other, ostensibly, more powerful instruments used in the CIF at the present time. Finally, the actively shielded magnet provides for a much smaller overall system footprint and will allow us to make better use of valuable CORE laboratory space in our new Chemistry building. The new 400 NMR will serve NIH and other funded projects involved with synthesis, catalysis, chemical biology, medicinal chemistry, bio--‐polymer chemistry, light harvesting and many others. There are more than a dozen NIH projects supported by this proposal and a similar number of projects funded by other agencies, private foundations and groups. The demise of Agilent NMR in the market place makes this an especially timely proposal.

描述（由申请人提供）：科罗拉多州立大学化学系正在申请资金购买一台新的 400 MHz NMR 波谱仪，该波谱仪将用 Mercury-Plus 控制台取代已有 18 年历史的 Varian 300 MHz NMR。该仪器将在中央仪器设施 (CIF) 内进行管理，该设施是科罗拉多州立大学化学系的基础核心。该仪器将位于全新的 CORE 实验室，该实验室是正在建设的新化学大楼的一部分。目前，我们的 NMR 工作大部分是在四台瓦里安 NMR 仪器上完成的，质子频率范围为 300 至 500 MHz。其中之一（本提案的主题）需要更换。这款 7.2 特斯拉、300 MHz 核磁共振磁体没有屏蔽，控制台电子设备已经过了其鼎盛时期并出现故障，噪音相对较大，功能有限，且维修或更换具有挑战性。探头已经磨损，性能相对较差，坦率地说，是易碎的古董。尽管如此，300 NMR 仍然以自助式、无需预约的模式进行常规 NMR 研究。相比之下，拟议的 400 NMR 将支持完全自动化，配备样品更换器、自动化高性能室温探头和液氮冷却冷探头。电磁阀将主动屏蔽，并具有长保持氦杜瓦瓶，这在与我们新的、内部资助的氦液化项目相结合时将具有优势。磁场控制、控制台技术、冷与它所取代的 NMR 相比，探头、进样器和先进的软件可提供显着更好的灵敏度、分辨率和性能。事实上，核磁共振性能足够好，我们期望进行某些类型的核磁共振，例如核磁共振。 13C 和快速 2D，在这个新的 400 NMR 上，而不是在目前 CIF 中使用的其他表面上更强大的仪器上。最后，主动屏蔽磁体提供了更小的整体系统占地面积，并使我们能够更好地利用新化学大楼中宝贵的核心实验室空间。新的 400 NMR 将为 NIH 和其他涉及合成、催化、化学生物学、药物化学、生物聚合物化学、光捕获等领域的资助项目提供服务。该提案支持了十多个 NIH 项目，以及其他机构、私人基金会和团体资助的类似数量的项目。灭亡安捷伦 NMR 在市场上的广泛应用使得这是一个特别及时的建议。