Cognitive Aging in a Population-Based Sample of Older Adults in Puerto Rico

描述（由申请人提供）：我们提出了一个为期两年的探索性/发展项目，以检查第一个基于人口的，全岛的社区居住的波多黎各人年龄60岁及以上的研究认知结果的预测。对波多黎各主岛的住户进行了访问，以确定4 291名参与者的目标样本， 波多黎各老年人：健康状况（PREHCO）研究。这项建议利用丰富的生命历程数据来调查理论驱动的假设，可能影响认知老化的因素。总体目标是：（a）分析现有的生命历程和认知数据，（B）通过对教育和职业因素进行更精确的评估来丰富数据，以及（c）将该项目用作PREHCO样本纵向随访的跳板，以收集更多的认知数据以及与检查认知老化相关的新的遗传和生物标志物数据。在这项探索性研究中，我们建议通过收集有关早期教育质量的新数据，以及成年后职业复杂性和工作压力的新数据，扩大PREHCO中可用的生命历程措施，以获得与老年人认知功能相关的环境因素的全面记录。该项目还将使我们能够提供第一个基于人口的规范性数据， 在波多黎各的老年人中的认知表现，并实施基于回归的截止值，以确定认知障碍与西班牙语的措施。总体假设是，与社会经济地位（SES），环境复杂性和整个生命过程中的压力相关的潜在可修改因素将是晚年认知结果的预测因素。这一初步发展项目将加强随后的研究建议，以跟踪PREHCO样本（目前年龄70岁以上）。

DESCRIPTION (provided by applicant): We propose a two-year exploratory/developmental project to examine predictors of cognitive outcomes in the first population-based, island-wide study of community-dwelling Puerto Ricans age 60 and older. Households across the main island of Puerto Rico were visited in order to identify the target sample of 4,291 participants for the Puerto Rican Elderly: Health Conditions (PREHCO) study. This proposal takes advantage of rich life course data to investigate theory- driven hypotheses about factors that may influence cognitive aging. The overarching goals are to (a) analyze the existing life course and cognitive data, (b) enrich the data with more refined assessment of educational and occupation-based factors, and (c) use this project as a springboard for a longitudinal follow-up of the PREHCO sample for the purpose of collecting additional cognitive data as well as new genetic and biomarker data relevant to examining cognitive aging. In this exploratory study, we propose to expand life course measures available in PREHCO by gathering novel data on quality of education in early-life, and on occupational complexity and job strain in adulthood, in order to obtain a comprehensive record of environmental factors relevant to cognitive function in older adulthood. This project will also allow us to provide the first population-based normative data for cognitive performance among older adults in Puerto Rico, and to implement regression-based cutoffs for determining cognitive impairment with a Spanish language measure. The overall hypothesis is that potentially modifiable factors related to socioeconomic status (SES), environmental complexity, and stress across the life course will be predictors of cognitive outcomes in later life. This initial developmental project will strengthen a subsequent research proposal to follow-up the PREHCO sample (currently age 70+).