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Cognitive Aging in a Population-Based Sample of Older Adults in Puerto Rico

波多黎各老年人群体样本的认知老化

基本信息

批准号：
9143627
负责人：
Michael Gabriel Crowe
金额：
$ 18.34万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-15 至 2019-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9143627
关键词：
Adult African American Age Aging Behavioral Blood Vessels Childhood Classification Code Cognitive Cognitive aging Collection Communities Complement County Cross-Cultural Comparison Data Data Collection Development Disadvantaged Education Educational Assessment Educational Background Elderly Environmental Risk Factor Epidemiologic Studies Exploratory/Developmental Grant Funding Future Future Teacher Genetic Markers Goals Health Hispanic Americans Hispanics Home environment Household Impaired cognition Impairment Individual Island Knowledge Language Life Life Cycle Stages Link Measures Mediating Mexican Mexican Americans Minority Minority Groups Municipalities National Institute on Aging Occupational Occupations Outcome Paper Participant Population Puerto Rican Puerto Rico Records Reporting Research Research Proposals Resources Risk Risk Factors Sampling Schools Socioeconomic Status Stress Subgroup Visit Work base cognitive function cognitive performance cognitive testing ethnic minority population follow-up gene environment interaction high school novel population based public health relevance residence social socioeconomic disadvantage socioeconomics theories

项目摘要

DESCRIPTION (provided by applicant): We propose a two-year exploratory/developmental project to examine predictors of cognitive outcomes in the first population-based, island-wide study of community-dwelling Puerto Ricans age 60 and older. Households across the main island of Puerto Rico were visited in order to identify the target sample of 4,291 participants for the Puerto Rican Elderly: Health Conditions (PREHCO) study. This proposal takes advantage of rich life course data to investigate theory- driven hypotheses about factors that may influence cognitive aging. The overarching goals are to (a) analyze the existing life course and cognitive data, (b) enrich the data with more refined assessment of educational and occupation-based factors, and (c) use this project as a springboard for a longitudinal follow-up of the PREHCO sample for the purpose of collecting additional cognitive data as well as new genetic and biomarker data relevant to examining cognitive aging. In this exploratory study, we propose to expand life course measures available in PREHCO by gathering novel data on quality of education in early-life, and on occupational complexity and job strain in adulthood, in order to obtain a comprehensive record of environmental factors relevant to cognitive function in older adulthood. This project will also allow us to provide the first population-based normative data for cognitive performance among older adults in Puerto Rico, and to implement regression-based cutoffs for determining cognitive impairment with a Spanish language measure. The overall hypothesis is that potentially modifiable factors related to socioeconomic status (SES), environmental complexity, and stress across the life course will be predictors of cognitive outcomes in later life. This initial developmental project will strengthen a subsequent research proposal to follow-up the PREHCO sample (currently age 70+).

描述（由申请人提供）：我们提出了一个为期两年的探索/发展项目，以检查认知结果的预测因素，这是第一个针对 60 岁及以上社区居住的波多黎各人的基于人口的全岛研究。对波多黎各主岛的家庭进行了走访，以确定 4,291 名参与者的目标样本波多黎各老年人：健康状况 (PREHCO) 研究。该提案利用丰富的生命历程数据来研究有关可能影响认知衰老的因素的理论驱动假设。总体目标是（a）分析现有的生命历程和认知数据，（b）通过对教育和职业因素进行更精细的评估来丰富数据，以及（c）使用该项目作为对 PREHCO 样本进行纵向随访的跳板，以收集额外的认知数据以及与检查认知老化相关的新遗传和生物标记数据。在这项探索性研究中，我们建议通过收集有关早期教育质量以及成年期职业复杂性和工作压力的新数据来扩展 PREHCO 中可用的生命历程测量，以获得与老年认知功能相关的环境因素的全面记录。该项目还将使我们能够提供第一个基于人口的规范数据波多黎各老年人的认知表现，并实施基于回归的临界值，通过西班牙语测量来确定认知障碍。总体假设是，与社会经济地位（SES）、环境复杂性和整个生命过程中的压力相关的潜在可改变因素将是晚年认知结果的预测因素。这个最初的开发项目将加强后续研究计划，以跟踪 PREHCO 样本（目前年龄 70 岁以上）。