Aging in Puerto Rico: Longitudinal Follow-Up of the PREHCO Study

波多黎各的老龄化：PREHCO 研究的纵向追踪

• 批准号: 10310713
• 负责人: Michael Gabriel Crowe
• 金额: $ 14.5万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10310713
• 关键词: Adult; Age; Aging; Chronic; Cognitive; Communities; Cross-Cultural Comparison; Data; Elderly; Environment; Event; Hair; Health; Health and Retirement Study; Healthcare; Household; Housing; Hurricane; Hydrocortisone; Impaired cognition; Island; Life Cycle Stages; Link; Measures; Mental Health; Neighborhoods; Outcome; Participant; Pathway interactions; Personal Satisfaction; Physical Function; Policies; Population; Population Study; Proxy; Puerto Rican; Puerto Rico; Research; Sampling; Social Environment; Stress; Survivors; Time; Visit; Vulnerable Populations; age group; aging in place; aging population; biopsychosocial; cognitive function; cohort; design; disability; enhancing factor; experience; follow-up; hazard; home test; hypothalamic-pituitary-adrenal axis; informant; insight; migration; mortality; perceived stress; population based; resilience; social determinants; stressor

In the past decade, Puerto Rico has experienced rapid population aging, financial collapse, mass outward migration of younger people, and then Hurricane Maria. Now is an ideal time to build on the only population-based cohort of older adults in Puerto Rico, unique in having data on health and function prior to these major events. Households across Puerto Rico were visited to identify the first island-wide sample of adults age 60+ years for the Puerto Rican Elderly: Health Conditions (PREHCO) study. A wide range of measures relevant to health and aging, including in-home testing of cognitive and physical function, was collected at baseline (2002/2003; N=4,291) and four years later (2006/2007; N=3,891). We propose to gather two new waves of data related to aging, stress and health in a sample of approximately 1,000 PREHCO survivors. The current project will a) extend PREHCO follow-up to between 16 and 20 years after baseline; b) examine life course predictors of major aging outcomes, namely cognitive impairment, disability, and mortality; c) collect data on hurricane-related stressors and mental health; d) add hair cortisol as a marker of chronic hypothalamic pituitary adrenal (HPA) axis activation; and e) add cognitive and proxy informant measures that align with the Health and Retirement Study (HRS). Our project will enable the following specific aims: Aim 1. Examine longitudinal life course biopsychosocial predictors of cognitive health, cortisol levels, mental health, disability, and mortality 16- 20 years after baseline. Aim 2. Examine cross-sectional associations between stressors, resilience-enhancing factors, perceived stress, cortisol, and health, as well as changes in health two years later. Aim 3. Increase utility of PREHCO for cross-cultural comparisons. Puerto Rico is an important part of the U.S. that has largely been omitted from U.S. population-based studies of aging. PREHCO participants are now age 76+ years and given accelerating mortality rates for this age group, our proposal to gather two new time points of follow-up data for PREHCO represents a time-limited opportunity to add to our knowledge about aging, stress, and health in an understudied and potentially vulnerable population.

在过去的十年里，波多黎各经历了人口迅速老龄化，金融崩溃，大规模向外 年轻人的移民，然后是飓风玛丽亚现在是一个理想的时机， 波多黎各的老年人队列，在这些主要研究之前， 事件访问了波多黎各各地的家庭，以确定第一个全岛60岁以上成年人的样本 波多黎各老年人：健康状况（PREHCO）研究。一系列广泛的措施， 健康和衰老，包括认知和身体功能的家庭测试，在基线时收集 (2002/2003; N= 4，291）和4年后（2006/2007; N= 3，891）。我们建议收集两波新的数据 在大约1 000名PREHCO幸存者的样本中，研究了与衰老、压力和健康有关的问题。当前项目 将a）将PREHCO随访延长至基线后16至20年; B）检查生命周期预测因素 主要老龄化结果，即认知障碍，残疾和死亡率; c）收集飓风相关数据 应激源和心理健康; d）添加毛发皮质醇作为慢性下丘脑垂体肾上腺皮质激素 (HPA)轴激活;和e）添加与健康和健康相关的认知和代理线人措施， 退休研究（HRS）。我们的项目将实现以下具体目标：目标1。检查纵向寿命 认知健康、皮质醇水平、心理健康、残疾和死亡率的生物心理社会预测因子 基线后20年。目标2.检查压力源之间的横截面关联， 因素，感知压力，皮质醇和健康，以及两年后健康的变化。目标3.提高效用 进行跨文化比较。波多黎各是美国的重要组成部分， 从美国人口老龄化研究中省略。PREHCO参与者现在年龄超过76岁， 由于该年龄组的死亡率不断上升，我们建议收集两个新的随访数据时间点， PREHCO代表了一个有时间限制的机会，以增加我们对衰老，压力和健康的知识， 未被充分研究的潜在弱势群体