Archiving the Complete Data Set from the Oregon Youth Substance Use Project.

摘要 拟议项目的首要目标是将俄勒冈州最新的评估存档 青年药物使用项目(OYSUP；RO1DA10767；RC2DA28793)。OYSUP的研究始于1998年， 年，在一个工人阶级社区的一个学区内招募了1075名一年级到五年级的学生 俄勒冈州西部。参与者代表了该学区的所有学生。一个队列序列 使用具有大约年度评估的设计来跟踪这五个等级超过三个等级的队列 发育阶段、童年、青春期和成年初期。参与者、家长和教师 从一年级到五年级到高中后一年每年都要进行评估，最低 自然减员。还获得了学校记录，并记录了人口普查区块。2012年，我们将所有 从儿童早期到高中后一年的OYSUP数据与国家成瘾和艾滋病毒数据 大学间政治和社会研究联盟档案计划(NAHDAP) 密歇根大学(ICPSR)，我们在那一天收集的。我们现在正在申请资金来完成 归档过程，添加在成年初期收集的上下文、生物和基因数据 OYSUP参与者的年龄在19-26岁之间。具体目标是：(1)对20-22岁参与者的数据进行归档 评估包括：(A)对20-22岁青少年进行诊断性访谈，包括症状和DSM-IV 诊断，(B)特里尔社会压力测试(Kirschbaum等人，1993)的数据，包括皮质醇水平 随着时间的推移，影响评级和心率的时间，以及(C)参与者和家长问卷。(2) 将20-22岁参与者的数据归档，主要是两组(第2组和第3组 T1级；n=403)。这些数据包括与压力/奖励相关的候选基因的多态。 途径和HPA轴的功能，与应激有关的RNA数据，以及两次访谈的结果， 生活事件和困难量表(LEDS；Brown&Harris，1978)，评估事件(间歇性压力)和 过去一年的困难(慢性压力)和儿童经历和护理评估(CECA；Bifulco， 等人，1994)来评估儿童时期的反感、忽视和虐待。(3)20-26岁时收集的档案数据 评估新烟草/尼古丁产品的使用情况和对使用情况的认识(A)两份问卷 评估，相隔11个月；和(B)面谈，评估使用情况的微观背景 至少试用了一种产品两次，或在两次评估之间更改了使用；以及(C)时间线跟踪 与这些参与者一起评估双重用途和使用顺序，以及(4)通过添加 最小的高中后一年评估的家长和参与者的问卷数据 一群人。由此产生的完整OYSUP数据集的归档将使未来合格的研究人员能够 在一个有代表性的工薪阶层中，调查从一年级到26岁期间使用药物的原因 通过利用这一丰富的多源、多级别数据数组进行示例。

ABSTRACT The overarching goal of the proposed project is to archive the most recent assessments from the Oregon Youth Substance Use Project (OYSUP; RO1DA10767; RC2DA28793). The OYSUP study began in 1998, with the recruitment of 1075 first through fifth graders within a single school district in a working class community in Western Oregon. Participants were representative of all students in the school district. A cohort sequential design with approximately annual assessments was used to follow these five grade cohorts over three developmental periods, childhood, adolescence, and emerging adulthood. Participants, parents and teachers were assessed annually from the 1st through the 5th grade through one-year post-high school, with minimal attrition. School records were also obtained and census blocks were recorded. In 2012, we archived all OYSUP data from early childhood through one-year post high school with the National Addiction & HIV Data Archive Program (NAHDAP) at the Inter-University Consortium for Political and Social Research at the University of Michigan (ICPSR) that we had collected by that date. We are now asking for funding to complete the archiving process, adding contextual, biological and genetic data collected in emerging adulthood when OYSUP participants were aged 19-26. The specific aims are: (1) Archive data from the age 20-22 participant assessments including (a) the diagnostic interview with 20-22 year olds, including symptoms and DSM-IV diagnoses, (b) data from the Trier Social Stress Test (Kirschbaum et al., 1993), including levels of cortisol across time, affect ratings and heart rate across time, and (c) the participant and parent questionnaires. (2) Archive data from 20-22 year old participants in primarily two cohorts (cohorts who were in the 2nd and 3rd grade at T1; n = 403). These data include polymorphisms of candidate genes related to the stress/reward pathway and the functioning of the HPA axis, RNA data related to stress, and the results of two interviews, the Life Events and Difficulty Schedule (LEDS; Brown & Harris, 1978), to assess events (episodic stress) and difficulties (chronic stress) over the past year and the Child Experiences and Care assessment (CECA; Bifulco, et al., 1994) to assess antipathy, neglect, and abuse in childhood. (3) Archive data collected at ages 20 – 26 assessing novel tobacco/nicotine product use and cognitions regarding use from (a) two questionnaire assessments, 11 months apart, and (b) an interview assessing the micro-context of use with those who had tried a product at least twice, or changed their use between assessments; and (c) a Time Line Follow-Back with these participants to assess dual use and order of use, and (4) Complete the archived data set by adding parent and participant questionnaire data from the one-year post-high school assessment for the youngest cohort. The resulting archive of the complete OYSUP data set will enable future qualified researchers to investigate the etiology of substance use from first grade through age 26 in a representative working class sample by drawing on this rich array of multi-source, multi-level data.