Archiving the Complete Data Set from the Oregon Youth Substance Use Project.

存档俄勒冈州青少年药物使用项目的完整数据集。

• 批准号: 9162217
• 负责人: Judy A Andrews
• 金额: $ 7.78万
• 依托单位: OREGON RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-15 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9162217
• 关键词: Adolescence; Adult; Affect; Age; Alcohol or Other Drugs use; Archives; Back; Biological; Biological Factors; Candidate Disease Gene; Caring; Censuses; Child; Childhood; Chronic stress; Cognition; Communities; DSM-IV; Data; Data Set; Development; Diagnosis; Diagnostic; Distal; Etiology; Event; Funding; Future; Genetic; Genetic Polymorphism; Goals; Grant; HIV; Heart Rate; Hydrocortisone; Interview; Life; Life Stress; Longitudinal Studies; Michigan; Nicotine; Oregon; Parents; Participant; Pathway interactions; Persons; Prevalence; Process; Qualifying; Questionnaires; RNA; Records; Research; Research Personnel; Rewards; Risk; Saliva; Sampling; Schedule; Schools; Source; Stress; Students; Substance Use Disorder; Symptoms; Time; Tobacco; Trier Social Stress Test; United States Substance Abuse and Mental Health Services Administration; Universities; Work; abuse neglect; addiction; adolescent substance use; aged; base; cohort; data archive; design; early childhood; emerging adulthood; experience; fifth grade; first grade; genetic analysis; high risk; high school; novel; programs; response; school district; second grade; social; stress reactivity; teacher; third grade

ABSTRACT The overarching goal of the proposed project is to archive the most recent assessments from the Oregon Youth Substance Use Project (OYSUP; RO1DA10767; RC2DA28793). The OYSUP study began in 1998, with the recruitment of 1075 first through fifth graders within a single school district in a working class community in Western Oregon. Participants were representative of all students in the school district. A cohort sequential design with approximately annual assessments was used to follow these five grade cohorts over three developmental periods, childhood, adolescence, and emerging adulthood. Participants, parents and teachers were assessed annually from the 1st through the 5th grade through one-year post-high school, with minimal attrition. School records were also obtained and census blocks were recorded. In 2012, we archived all OYSUP data from early childhood through one-year post high school with the National Addiction & HIV Data Archive Program (NAHDAP) at the Inter-University Consortium for Political and Social Research at the University of Michigan (ICPSR) that we had collected by that date. We are now asking for funding to complete the archiving process, adding contextual, biological and genetic data collected in emerging adulthood when OYSUP participants were aged 19-26. The specific aims are: (1) Archive data from the age 20-22 participant assessments including (a) the diagnostic interview with 20-22 year olds, including symptoms and DSM-IV diagnoses, (b) data from the Trier Social Stress Test (Kirschbaum et al., 1993), including levels of cortisol across time, affect ratings and heart rate across time, and (c) the participant and parent questionnaires. (2) Archive data from 20-22 year old participants in primarily two cohorts (cohorts who were in the 2nd and 3rd grade at T1; n = 403). These data include polymorphisms of candidate genes related to the stress/reward pathway and the functioning of the HPA axis, RNA data related to stress, and the results of two interviews, the Life Events and Difficulty Schedule (LEDS; Brown & Harris, 1978), to assess events (episodic stress) and difficulties (chronic stress) over the past year and the Child Experiences and Care assessment (CECA; Bifulco, et al., 1994) to assess antipathy, neglect, and abuse in childhood. (3) Archive data collected at ages 20 – 26 assessing novel tobacco/nicotine product use and cognitions regarding use from (a) two questionnaire assessments, 11 months apart, and (b) an interview assessing the micro-context of use with those who had tried a product at least twice, or changed their use between assessments; and (c) a Time Line Follow-Back with these participants to assess dual use and order of use, and (4) Complete the archived data set by adding parent and participant questionnaire data from the one-year post-high school assessment for the youngest cohort. The resulting archive of the complete OYSUP data set will enable future qualified researchers to investigate the etiology of substance use from first grade through age 26 in a representative working class sample by drawing on this rich array of multi-source, multi-level data.

抽象的 拟议项目的总体目标是存档俄勒冈州的最新评估 青少年药物使用项目（OYSUP；RO1DA10767；RC2DA28793）。 OYSUP 研究始于 1998 年， 在一个工人阶级社区的一个学区内招募了 1075 名一年级至五年级的学生 俄勒冈州西部。参与者代表了学区的所有学生。队列顺序 采用大约每年一次的评估设计来跟踪这五个年级的学生超过三年 发育期、儿童期、青春期和成年初期。参与者、家长和老师 从一年级到五年级直至高中毕业后一年，每年都会进行评估，最低限度 磨损。还获得了学校记录并记录了人口普查区块。 2012年，我们将所有 OYSUP 从幼儿期到高中毕业后一年的数据以及国家成瘾和艾滋病毒数据 大学间政治和社会研究联盟的档案计划（NAHDAP） 我们截至该日期收集的密歇根大学 (ICPSR)。我们现在正在寻求资金来完成 归档过程，添加在成年初期收集的背景、生物和遗传数据 OYSUP 参与者年龄为 19-26 岁。具体目标是： (1) 归档 20-22 岁参与者的数据 评估包括 (a) 对 20-22 岁的人进行诊断访谈，包括症状和 DSM-IV 诊断，(b) 来自特里尔社会压力测试的数据（Kirschbaum 等，1993），包括皮质醇水平 随时间变化的影响评分和心率，以及 (c) 参与者和家长问卷调查。 (2) 存档数据主要来自两个队列（第二组和第三组）的 20-22 岁参与者 T1级； n = 403）。这些数据包括与压力/奖励相关的候选基因的多态性 HPA 轴的通路和功能、与压力相关的 RNA 数据以及两次访谈的结果， 生活事件和难度表（LEDS；Brown & Harris，1978），用于评估事件（情景压力）和 过去一年的困难（慢性压力）以及儿童经历和护理评估（CECA；Bifulco， et al., 1994）来评估童年时期的反感、忽视和虐待。 (3) 20 – 26 岁收集的档案数据 通过 (a) 两份问卷评估新型烟草/尼古丁产品的使用和对使用的认知 评估，相隔 11 个月，以及 (b) 访谈，评估使用过的人的微观环境 至少尝试过一种产品两次，或在评估之间改变了其用途； (c) 时间线跟进 与这些参与者一起评估双重使用和使用顺序，以及 (4) 通过添加来完成存档数据集 家长和参与者问卷数据来自对最小的孩子高中毕业后一年的评估 队列。完整 OYSUP 数据集的最终存档将使未来合格的研究人员能够 调查具有代表性的工人阶级从一年级到 26 岁的物质使用病因 通过利用这些丰富的多源、多层次数据来进行示例。