National Emerging Infectious Diseases Laboratories Operations

 描述(由申请人提供)： 概述：波士顿大学的国家生物遏制实验室(NBL)被称为国家新发传染病实验室(NEIDL)。Neidl由波士顿大学(BU)拥有和运营，位于波士顿大学医学院(BUMC)。NIDL的使命是：1.对新出现的传染病进行尖端的基础、转化和临床研究，包括A、B和C类药物，以开发诊断测试、治疗和疫苗，以促进公众健康；2.提供这些研究领域的培训，并在发生生物防御紧急情况时支持国家反应；以及3.建立最关注社区和实验室安全和安保的研究设施。为了成功地完成这些任务，NIDL的目标是：1)招募和发展一支具有所需科学学科专业知识的调查人员和研究人员队伍，以调查由A、B和C类病原体引起的新出现的传染病的发病机制；2)开发动物模型，用于对这些病原体进行比较研究，尽可能接近人类的疾病过程；3)在动物和人类身上进行翻译、临床前和临床研究；4)开发所需的方法学，以促进这些病原体的疫苗、治疗和诊断的开发和测试；5)对科学家和相关支助人员进行培训，使他们了解在安全和有保障的环境中进行最大限度遏制研究的要求；6)保持必要的灵活性，以便在发生生物防御紧急情况时支持国家反应；7)为研究所开展的所有活动建立一个“安全第一”的环境。

 DESCRIPTION (provided by applicant): Overall: Summary The National Biocontainment Laboratory (NBL) at Boston University is known as the National Emerging Infectious Diseases Laboratories (NEIDL). The NEIDL is owned and operated by Boston University (BU) and is located on the Boston University Medical Campus (BUMC). The NEIDL's missions are: 1. To perform cutting- edge basic, translational and clinical research on emerging infectious diseases, including category A, B, and C agents, in order to develop diagnostic tests, treatments and vaccines to promote the public's health; 2. To provide training in these areas of research and to support a national response in the event of a biodefense emergency; and 3. To establish a research facility with the highest attention to community and laboratory safety and security. In order to successfully achieve these missions, the NEIDL's goals are to: 1) Recruit and develop a cadre of investigators and research staff with expertise in the scientific disciplines required to investigate the pathogenesis of emerging infectious diseases caused by category A, B and C agents; 2) Develop animal models for the comparative study of these pathogens, mimicking as closely as possible the human disease process; 3) Perform translational, preclinical and clinical research in animals and humans; 4) Develop the methodologies needed to advance the development and testing of vaccines, therapeutics and diagnostics for these agents; 5) Train scientists and related support personnel in the requirements to perform maximum containment research in a safe and secure environment; 6) Maintain the flexibility needed to support a national response in the event of a biodefense emergency; 7) Establish a "safety first" environment for the conduct of all activities i the Institute.