National Emerging Infectious Diseases Laboratories Operations

 描述（由申请人提供）： 总体情况：波士顿大学的国家生物防护实验室（NBL）被称为国家新发传染病实验室（NEIDL）。NEIDL由波士顿大学（BU）拥有和运营，位于波士顿大学医学校区（BUMC）。NEIDL的任务是：1。就新出现的传染病（包括甲类、B类和C类病原体）进行最先进的基础、转化和临床研究，以开发诊断测试、治疗方法和疫苗，促进公众健康; 2.在这些研究领域提供培训，并在发生生物防御紧急情况时支持国家应对措施;建立一个高度重视社区和实验室安全和安保的研究设施。为了成功地完成这些任务，NEIDL的目标是：（1）招募和培养一批具有调查A、B和C类物剂引起的新出现的传染病发病机理所需的科学学科专门知识的调查人员和研究人员;（2）开发动物模型，用于对这些病原体进行比较研究，尽可能模拟人类疾病过程; 3）在动物和人类中进行转化、临床前和临床研究; 4）制定必要的方法，以推动这些物剂的疫苗、治疗剂和诊断剂的开发和测试; 5）培训科学家和相关支助人员，使其了解在安全和有保障的环境中进行最大限度遏制研究的要求; 6）保持必要的灵活性，以支持在生物防御紧急情况下的国家反应; 7）建立一个“安全第一”的环境，在研究所的所有活动的行为。

 DESCRIPTION (provided by applicant): Overall: Summary The National Biocontainment Laboratory (NBL) at Boston University is known as the National Emerging Infectious Diseases Laboratories (NEIDL). The NEIDL is owned and operated by Boston University (BU) and is located on the Boston University Medical Campus (BUMC). The NEIDL's missions are: 1. To perform cutting- edge basic, translational and clinical research on emerging infectious diseases, including category A, B, and C agents, in order to develop diagnostic tests, treatments and vaccines to promote the public's health; 2. To provide training in these areas of research and to support a national response in the event of a biodefense emergency; and 3. To establish a research facility with the highest attention to community and laboratory safety and security. In order to successfully achieve these missions, the NEIDL's goals are to: 1) Recruit and develop a cadre of investigators and research staff with expertise in the scientific disciplines required to investigate the pathogenesis of emerging infectious diseases caused by category A, B and C agents; 2) Develop animal models for the comparative study of these pathogens, mimicking as closely as possible the human disease process; 3) Perform translational, preclinical and clinical research in animals and humans; 4) Develop the methodologies needed to advance the development and testing of vaccines, therapeutics and diagnostics for these agents; 5) Train scientists and related support personnel in the requirements to perform maximum containment research in a safe and secure environment; 6) Maintain the flexibility needed to support a national response in the event of a biodefense emergency; 7) Establish a "safety first" environment for the conduct of all activities i the Institute.