National Emerging Infectious Diseases Laboratories Operations

描述(由申请人提供)： 国家新发传染病实验室(NEIDL)研究所的总体目标是取得基础性发现，从而预防和控制世界上新发和再次出现的传染病。传染病是全球发病率和死亡率的单一最易改变的原因，影响到全球人口的很大一部分，并对婴儿、儿童和处于生产最旺盛年龄段的成年人造成特别沉重的损失，对家庭、地方和全球经济造成毁灭性影响。Neidl研究所利用聚集在一个地点的所有尖端研究技术平台，以及创新的教师和具有战略意义的国内和国际合作伙伴，通过合作研究团队的努力，寻求解决预防和控制新出现的传染病的关键和基本知识障碍。NEIDL建立在这样一种理念之上：将现代科学学科的发现工具箱高度包容地提供给免疫学、微生物学、遗传学和传染病专家，并将重点放在传染病发现研究上，这将是最令人兴奋和富有成效的早期研究框架，最终将导致针对新出现的传染病开发疫苗、治疗和控制措施。一系列全面的研究技术和传染病模型可以应用于最关键的新出现的传染病，包括流感(包括高致病性和流行性菌株)、结核病(包括多重和广泛的抗药性菌株)、蚊子和壁虱传播的传染病(包括出血热和脑炎病毒)以及抗药性病原体。最先进的设施占地约192,000平方英尺，设计时高度重视安全和安保。Neidl设施拥有高密封性的BSL-4研究实验室和相关的支持实验室、机械、临床研究和行政空间。该研究所由代表五个职能领域的18个核心组成，所有这些核心都支持BSL-4实验室。这些核心分为5个领域，包括设施维护和运营、生物安全、环境健康和安全法规和要求、法规遵从性以及综合研究支持服务。

DESCRIPTION (provided by applicant): The overall goal of the National Emerging Infectious Diseases Laboratories (NEIDL) Institute is to make fundamental discoveries that lead to the prevention and control of the world's emerging and re-emerging infectious diseases. Infectious diseases are the single most modifiable cause of worldwide morbidity and mortality affecting large sectors of the global population and exacting a particularly heavy toll on infants, children and adults in their most productive years, with devastating effects on families and local and global economies. Using the full spectrum of cutting edge research technology platforms assembled in one location with innovative faculty and strategic domestic and international collaborators the NEIDL Institute seeks to address critical and fundamental knowledge barriers to the prevention and control of emerging infectious diseases through the efforts of collaborating research teams. The NEIDL Is built on the philosophy that making available in high containment the discovery toolboxes of modern scientific disciplines to experts in immunology, microbiology, genetics and infectious diseases with a singular focus on infectious diseases discovery research will be the most exciting and productive framework for early stage research that will ultimately lead to the development of vaccines, treatments and control measures for emerging infectious diseases. A comprehensive array of research technologies and infectious disease models can be brought to bear on the most critical emerging infectious diseases including influenza (including highly pathogenic and epidemic strains), tuberculosis (including multi- and extensive drug resistant strains), mosquito and tick insect transmitted infectious diseases (including hemorrhagic fever and encephalitis viruses), and antibiotic resistant pathogens. The state of the art approximately 192,000 sq ft facility is designed with the highest attention to safety and security. The NEIDL facility houses high containment BSL-4 research laboratories and associated support laboratories, mechanical, clinical research and administrative spaces. The Institute is comprised of eighteen cores which represent five functional areas, all of which support the BSL-4 laboratories. These Cores are grouped under 5 areas that include facility maintenance and operations, biosecurity, environmental health and safety regulations and requirements, regulatory compliance, and integrated research support services.