Development and function of CD4+ memory T cells during malaria
Development and function of CD4+ memory T cells during malaria
批准号:
9157297
负责人:
Noah Sullivan Butler
金额:
$32.65万
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-06-15 至 2017-02-28
关键词:
AcuteAddressAdoptive TransferAntibodiesAntibody ResponseAntibody-mediated protectionAntigensBiochemicalBiologyBloodCD4 Positive T LymphocytesCell CountCellsChronicClinicalClinical TrialsCommunicable DiseasesComparative StudyContractsDataDevelopmentDiseaseEmergency SituationErythrocytesGeneticGoalsGrowthHelper-Inducer T-LymphocyteHumanHumoral ImmunitiesImmuneImmunityImmunologicsImmunotherapeutic agentInfectionInflammationInterferon Type IIInterventionLeadLifeMaintenanceMalariaMeasuresMediatingMemoryMethodsModelingMolecular ProfilingMusParasite ControlParasitesPathogenesisPathway interactionsPhenotypePlasmodiumPopulationPositioning AttributePublishingResearchResistanceResolutionRiskSeverity of illnessSignal TransductionStagingSymptomsT cell responseT-LymphocyteT-Lymphocyte EpitopesT-Lymphocyte SubsetsTestingTissuesTransgenic MiceVaccinationVaccinesVirus DiseasesWorkbaseburden of illnesscytokineglobal healthimmunopathologyimprovedinnovationinsightmemory CD4 T lymphocytenovelnovel strategiespathogenresearch study
中文摘要
疟原虫感染和疟疾仍然是全球突发卫生事件。疟原虫
英文摘要
Plasmodium infections and the disease malaria remain global health emergencies. Plasmodium parasites
replicate within and cause the destruction of host red blood cells, which triggers inflammation and causes the
symptoms of malarial disease. Parasite-specific antibody responses that develop following infection are critical
for controlling parasite burden and limiting disease severity. CD4+ helper T cells are essential for coordinating
these protective antibody responses. However, sterilizing anti-Plasmodium immunity rarely develops, even
following repeated infection. We hypothesize this is due to deficient Plasmodium-specific effector and memory
CD4+ T cell formation. One of the most critical challenges to developing new immune-based therapies or
vaccines against Plasmodium is understanding how or whether long-lived Plasmodium-specific memory CD4+
T cells develop, function and persist following infection. In this project we have developed powerful new
cellular, genetic and biochemical approaches that enable direct, high-resolution analyses of bona fide
Plasmodium-specific memory CD4+ T cells. These new approaches facilitate our long-term goal to understand
the quantity and quality of Plasmodium-specific memory CD4+ T cell responses. Our goal is addressed by
three specific aims that test: 1) the phenotype, function and numerical stability of Plasmodium-specific effector
and memory CD4+ T cell populations and their impact on protective humoral immunity; 2) how parasite- and
host-specific factors regulate the formation of long-lived memory CD4+ T cell responses; and 3) the effector
mechanisms and pathways that memory CD4+ T cells use to orchestrate long-lived anti-Plasmodium immunity.
Our innovative approaches enable us to establish additional new paradigms for understanding and enhancing
CD4+ T cell-dependent anti-Plasmodium immunity. Understanding immune memory formation following
Plasmodium infection will enable us to identify and develop new immune-based strategies to limit Plasmodium
pathogenesis and disease burden.
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会议论文
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批准号:10681616
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Mechanisms and consequences of extrafollicular B cell activation during malaria
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Mechanisms and consequences of extrafollicular B cell activation during malaria
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批准号:10494205
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项目类别:
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资助金额:$64.71万
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财政年份:2021
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负责人:Noah Sullivan Butler
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依托单位:
Mechanisms and consequences of extrafollicular B cell activation during malaria
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批准号:10686400
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项目类别:
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资助金额:$64.71万
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财政年份:2021
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负责人:Noah Sullivan Butler
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Development and function of CD4+ memory T cells during malaria
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批准号:10604910
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项目类别:
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资助金额:$46.65万
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财政年份:2016
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负责人:Noah Sullivan Butler
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依托单位:
Regulation of Plasmodium-specific CD4+ T cells
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批准号:10676649
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项目类别:
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资助金额:$46.65万
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财政年份:2016
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负责人:Noah Sullivan Butler
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依托单位:
Regulation of Plasmodium-specific CD4+ T Cells
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批准号:9214981
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项目类别:
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资助金额:$11.13万
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财政年份:2016
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负责人:Noah Sullivan Butler
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依托单位:
Role of CD4 T cell inhibitor receptors during Plasmodium blood stage infection
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批准号:8607494
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项目类别:
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资助金额:$10.8万
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财政年份:2013
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负责人:Noah Sullivan Butler
-
依托单位:
Role of CD4 T cell inhibitor receptors during Plasmodium blood stage infection
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批准号:8442603
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项目类别:
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资助金额:$16.2万
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财政年份:2013
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负责人:Noah Sullivan Butler
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依托单位:
Training in Mechanisms of Parasitism
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批准号:10426360
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项目类别:
-
资助金额:$40.48万
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财政年份:1996
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负责人:Noah Sullivan Butler
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依托单位:
Training in Mechanisms of Parasitism
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批准号:10653271
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项目类别:
-
资助金额:$40.43万
-
财政年份:1996
-
负责人:Noah Sullivan Butler
-
依托单位:
Training in Mechanisms of Parasitism
-
批准号:10271800
-
项目类别:
-
资助金额:$37.68万
-
财政年份:1996
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负责人:Noah Sullivan Butler
-
依托单位:
Interdisciplinary Immunology Postdoctoral Training Program
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批准号:10397083
-
项目类别:
-
资助金额:$37.05万
-
财政年份:1984
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负责人:Noah Sullivan Butler
-
依托单位:
Interdisciplinary Immunology Postdoctoral Training Program
-
批准号:10152494
-
项目类别:
-
资助金额:$27.45万
-
财政年份:1984
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负责人:Noah Sullivan Butler
-
依托单位:
Interdisciplinary Immunology Postdoctoral Training Program
-
批准号:10615642
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项目类别:
-
资助金额:$39.16万
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财政年份:1984
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负责人:Noah Sullivan Butler
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依托单位:
海外基金