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Monochromatic 222 nm UV light: Development of a safe, cost-effective technology for the efficient reduction of bacterial and viral infection and transmission

单色 222 nm 紫外线：开发安全、经济高效的技术，有效减少细菌和病毒的感染和传播

基本信息

批准号：
9140848
负责人：
DAVID JONATHAN BRENNER
金额：
$ 15万
依托单位：
EDEN PARK ILLUMINATION, INC.
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-03-15 至 2017-03-14
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Drug resistant bacteria, such as MRSA, and airborne-transmitted microbes, such as influenza and TB, together present major health issues both in the developed and the developing world, with major health care and economic consequences. Recent research from Columbia University Medical Center demonstrated that single- wavelength far-UVC photons can kill bacteria and viruses while it cannot penetrate either the human stratum corneum (the outer dead-cell skin layer), nor the ocular cornea, nor the corneal tear-film layer, nor even the cytoplasm of individual human cells. In particular, the results teste both in vitro and in vivo have shown that several far-UVC wavelengths (such as 207 and 222 nm) are as efficient as conventional mercury containing germicidal UV lamp in inactivating both drug-resistant bacteria (e.g. MRSA) and viruses (e.g. H1N1), but these two far UVC wavelengths induce no damage to skin or to eyes, for a wide range of clinical endpoints, in contrast to a conventional broad-spectrum germicidal lamp. In this program, the team of Columbia University and Eden Park Illumination propose a novel, efficient disinfection tool which can be scalable and affordable. The team will develop uniform and flat lamps having anti-microbial advantages over conventional cylindrical UV lamps, but without the safety hazards. Eden Park have commercialized a new generation of UV light tiles with a patented microcavity plasma technology, producing lamps with a scalable, slim form factor for uniformly treating large surfaces. Based on confinement of low temperature plasma within large arrays of microcavities, this technology is ideally-suited for the efficient, inexpensive production of excimer-based 222 nm UV lamp. The technology of a monochromatic excimer lamp emitting 222 nm UV radiation will have two initial applications: 1) reducing surgical site infections, in which 222 nm photons will continuously illuminate the wound during surgery, and 2) minimizing airborne transmission of microbes such as TB and influenza, in which whole-room illumination will be used. Both have been successfully demonstrated with conventional germicidal lamps but widespread use has been limited due to the associated health hazards of conventional lamps. The Phase I Project Aims are first, to design and develop 222 nm microplasma UV flat lamp optimized for this germicidal application, and second, to use the lamp to demonstrate effective germicidal properties. The first Aim will involve design and optimization of a microplasma-based monochromatic far-UVC flat lamp optimized for germicidal applications, with the milestone of a 222 nm flat UV lamp without higher wavelength "contaminants", and with a lamp structure and gas mixture optimized for long lifetime. The second Aim is to demonstrate the efficacy of this 222 nm microplasma flat lamp for anti-bacterial efficiency in an in vivo wound model and for anti-viral efficiency in an airborne aerosol model. The milestones here are to demonstrate appropriate levels of MRSA killing in a murine model of surgical site infection, and appropriate levels of H1N1 influenza virus killing in an airborne aerosol model.

描述（由申请人提供）：耐药性细菌（如MRSA）和空气传播的微生物（如流感和结核病）共同构成了发达国家和发展中国家的主要健康问题，带来了重大的医疗保健和经济后果。最近来自哥伦比亚大学医学中心的研究表明，单波长远UVC光子可以杀死细菌和病毒，而它既不能穿透人角质层（外部死细胞皮肤层），也不能穿透眼角膜，也不能穿透角膜泪膜层，甚至也不能穿透单个人细胞的细胞质。特别是，体外和体内测试的结果表明，几个远紫外线波长（例如207和222 nm）与传统的含汞杀菌紫外线灯一样有效地灭活两种耐药细菌（例如MRSA）和病毒（例如H1N1），但是这两个远UVC波长对于宽范围的临床终点不引起对皮肤或眼睛的损伤，这与常规的广谱杀菌灯形成对比。在这个项目中，哥伦比亚大学和伊甸公园照明公司的团队提出了一种新颖、高效的消毒工具，这种工具可以扩展，而且价格合理。该团队将开发均匀和扁平的灯，与传统的圆柱形紫外线灯相比具有抗菌优势，但没有安全隐患。伊甸园已经商业化的新一代紫外线瓷砖与专利微腔等离子体技术，生产灯与可扩展的，超薄的形状因素，均匀处理大表面。基于低温等离子体在大阵列微腔中的限制，该技术非常适合于基于准分子的222 nm UV灯的高效、廉价的生产。发射222 nm UV辐射的单色准分子灯技术将有两个最初的应用：1）减少手术部位感染，其中222 nm光子将在手术期间持续照射伤口，以及2）最大限度地减少结核病和流感等微生物的空气传播，其中将使用整个房间照明。这两种方法都已经用传统的杀菌灯成功地证明了，但由于传统灯的相关健康危害，广泛使用受到限制。第一阶段项目的目标是，首先设计和开发222 nm微等离子体UV平板灯，优化这种杀菌应用，其次，使用灯来证明有效的杀菌性能。第一个目标将涉及基于微等离子体的单色远紫外线平面灯的设计和优化，该灯针对杀菌应用进行了优化，其里程碑是没有更高波长“污染物”的222 nm平面紫外线灯，以及针对长寿命优化的灯结构和气体混合物。第二个目的是证明这种222 nm微等离子体平板灯在体内伤口模型中的抗菌效率和在空气中的气溶胶模型中的抗病毒效率的功效。这里的里程碑是证明在手术部位感染的鼠模型中适当水平的MRSA杀灭，以及在空气中的气溶胶模型中适当水平的H1N1流感病毒杀灭。

项目成果

期刊论文数量（4）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Far-UVC light: A new tool to control the spread of airborne-mediated microbial diseases.

DOI：
10.1038/s41598-018-21058-w
发表时间：
2018-02-09
期刊：
Scientific reports
影响因子：
4.6
作者：
Welch D;Buonanno M;Grilj V;Shuryak I;Crickmore C;Bigelow AW;Randers-Pehrson G;Johnson GW;Brenner DJ
通讯作者：
Brenner DJ

Germicidal Efficacy and Mammalian Skin Safety of 222-nm UV Light.

DOI：
10.1667/rr0010cc.1
发表时间：
2017-04
期刊：
Radiation research
影响因子：
3.4
作者：
Buonanno M;Ponnaiya B;Welch D;Stanislauskas M;Randers-Pehrson G;Smilenov L;Lowy FD;Owens DM;Brenner DJ
通讯作者：
Brenner DJ