课题基金 / 基金详情

Immune Modulation by Gammaherpesviruses

Immune Modulation by Gammaherpesviruses
伽玛疱疹病毒的免疫调节
批准号：
9089883
负责人：
LAURENT COSCOY
金额：
$23.42万
依托单位：
UNIVERSITY OF CALIFORNIA BERKELEY
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
项目状态：
已结题
起止时间：
2012-09-14 至 2017-06-30
来源：
https://reporter.nih.gov/project-details/9089883
关键词：
Acquired Immunodeficiency SyndromeAffectAnimal ModelAnimalsAntiviral AgentsAntiviral ResponseAttenuatedB-LymphocytesBiologicalCD8B1 geneCodeCollaborationsDevelopmentDiseaseEquilibriumFluorescenceForcible intercourseHuman Herpesvirus 8Immune responseImmune systemImmunocompromised HostImmunomodulatorsIndividualInfectionKaposi SarcomaKnowledgeLifeLymphoproliferative DisordersMusPathogenesisPathologyPatientsPhysiologicalProteinsSatellite VirusesSkin CancerTechniquesTransplant RecipientsVaccinesViralVirusadaptive immunitydrug developmentgammaherpesvirusimmunoregulationimprovedprimary effusion lymphomaresponsetraffickingvaccine development

项目摘要

项目成果

LAURENT COSCOY的其他基金

相似基金

相关文献

中文摘要
翻译
描述(由申请人提供)： 伽马疱疹病毒，如KSHV和MHV68，已经与宿主的免疫系统建立了微调的平衡。因此，这些病毒在其宿主中建立了终身持续感染，而不会引起重大病理变化。这些病毒编码的免疫调节蛋白可能是这种平衡的关键调节因子。我们的建议重点放在K3上，这是一种由KSHV和MHV68编码的蛋白质，可以减弱抗病毒CD8反应。我们的目标是了解这种蛋白质是如何调节的，以及我们是否可以绕过它的活性。我们相信，这些信息将被证明有助于KSHV疫苗的开发。
英文摘要
DESCRIPTION (provided by applicant): Gammaherpesviruses, such as KSHV and MHV68, have developed a fine-tune equilibrium with the immune system of their host. As a result, these viruses establish a life-long persistent infection in their host without causing significant pathologies. Immunomodulatory proteins encoded by these viruses are likely to be critical regulators of this equilibrium. Our proposal focuses on K3, a protein encoded by KSHV and MHV68 that attenuates the antiviral CD8 responses. We aim to understand how this protein is regulated and whether we could circumvent its activity. We believe that this information will prove to be instrumental for the development of a KSHV vaccine.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Presentation of Qa-1 restricted peptides during homeostasis and viral infection
Presentation of Qa-1 restricted peptides during homeostasis and viral infection
Presentation of Qa-1 restricted peptides during homeostasis and viral infection
Presentation of Qa-1 restricted peptides during homeostasis and viral infection
海外基金