Immune Modulation by Gammaherpesviruses

伽玛疱疹病毒的免疫调节

• 批准号: 8410071
• 负责人: LAURENT COSCOY
• 金额: $ 25.93万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-14 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8410071
• 关键词: Acquired Immunodeficiency Syndrome; Affect; Animal Model; Animals; Antiviral Agents; Antiviral Response; Attenuated; B-Lymphocytes; Biological; CD8B1 gene; Code; Collaborations; Development; Disease; Equilibrium; Fluorescence; Forcible intercourse; Human Herpesvirus 8; Immune response; Immune system; Immunocompromised Host; Immunomodulators; Individual; Infection; Kaposi Sarcoma; Knowledge; Life; Lymphoma; Lymphoproliferative Disorders; Mus; Pathogenesis; Pathology; Patients; Physiological; Proteins; Satellite Viruses; Skin Cancer; Techniques; Transplant Recipients; Vaccines; Viral; Virus; drug development; effusion; gammaherpesvirus; immunoregulation; improved; response; trafficking; vaccine development

DESCRIPTION (provided by applicant): Gammaherpesviruses, such as KSHV and MHV68, have developed a fine-tune equilibrium with the immune system of their host. As a result, these viruses establish a life-long persistent infection in their host without causing significant pathologies. Immunomodulatory proteins encoded by these viruses are likely to be critical regulators of this equilibrium. Our proposal focuses on K3, a protein encoded by KSHV and MHV68 that attenuates the antiviral CD8 responses. We aim to understand how this protein is regulated and whether we could circumvent its activity. We believe that this information will prove to be instrumental for the development of a KSHV vaccine. PUBLIC HEALTH RELEVANCE: This proposal aims at identifying mechanisms that will improve immune responses against Kaposi's sarcoma associated virus. Such knowledge will be instrumental for the development of drugs and/or vaccines against KSHV.

描述（由申请人提供）： KSHV 和 MHV68 等伽马疱疹病毒已与其宿主的免疫系统形成了微调平衡。结果，这些病毒在宿主体内建立了终生持续感染，而不会引起明显的病变。这些病毒编码的免疫调节蛋白可能是这种平衡的关键调节剂。我们的建议重点关注 K3，这是一种由 KSHV 和 MHV68 编码的蛋白质，可减弱抗病毒 CD8 反应。我们的目标是了解这种蛋白质是如何受到调节的以及我们是否可以规避其活性。我们相信这些信息将有助于 KSHV 疫苗的开发。 公共卫生相关性： 该提案旨在确定改善针对卡波西肉瘤相关病毒的免疫反应的机制。这些知识将有助于开发针对 KSHV 的药物和/或疫苗。