COBRE in Lipidomics and Pathobiology

描述(由申请人提供)：南卡罗来纳医科大学(MUSC)脂质组学和病理生物学新兴中心建立在Cobre的前两个阶段取得的重大成就的基础上。其中包括指导19名目标初级教研员，其中14人已获得独立的校外资助，目标教员在同行评议期刊上发表了193篇文章，超过25名南加州大学研究人员参与了COBRE活动，发展和加强了非常成功、创新的核心科学设施，包括一个独特的脂质组学核心，以及一个专注于动物病理生物学的新兴核心核心(专注于基于脂质的动物模型)和一个专注于脂酶和靶点的蛋白质核心。科布雷还非常成功地招聘了少数族裔(2名)和女性(10名)作为目标教员。组织假说指出，生物活性脂质和相关代谢物的宇宙构成了一个复杂的网络，由调节关键生理功能的不同途径组成。反过来，这些通路的功能障碍导致了特定疾病的病理生物学。平衡脂类的生物学意义是研究脂类和脂类相互作用蛋白相对困难的独特考虑因素。这就需要发展有能力的共享设施，并作出协作努力，使各种学科和专门知识适用于具体问题。因此，下一阶段的战略重点是在南加州大学建立一个独立的脂质组学和病理生物学中心，该中心将建立在这些卓越的科学和机构成就的基础上，并将继续推动南加州大学的脂质研究。总体目标是充分利用MUSC在脂质生物学方面的非凡优势，具体目标是：1)确定和开发以中心活动(如癌症、神经退行性变、代谢紊乱和感染/炎症)为基础的重要病理生物学的具体专题方案活动；2)加强翻译研究；3)加强指导，以应对当前资金环境日益严峻的挑战；4)加强核心的功能，使其能够更好地服务于专题和翻译目标；5)完成新型脂质组学门户网站的开发；以及6)开发和实现核心的可持续性。我们预计，这些活动将导致一个高度发展的跨学科研究中心，在一个对癌症生物学、衰老、炎症、糖尿病、神经退行性疾病和传染病具有重大意义的不断发展的研究领域，拥有大量合作、独立和以程序资助的研究人员。

DESCRIPTION (provided by applicant): The emerging Center in Lipidomics and Pathobiology at the Medical University of South Carolina (MUSC) builds on substantial accomplishments during the first two phases of the COBRE. These include mentoring of 19 targeted junior faculty investigators, 14 of whom have achieved independent extramural funding, 193 publications in peer-review journals by the target faculty, participation by more than 25 MUSC research faculty in COBRE activities, and development and enhancement of highly successful, innovative scientific core facilities, including a unique core in Lipidomics, and emerging focused cores in animal pathobiology (focused on lipid-based animal models) and a protein core focused on lipid enzymes and targets. The COBRE has also been very successful in recruiting minorities (2) and women (10) as target faculty. The organizing hypothesis states that the universe of bioactive lipids and related metabolites constitutes a complex network of diverse pathways regulating key physiologic functions. In turn, dysfunctions in these pathways contribute to the pathobiology of specific diseases. Counterbalancing the biological significance of lipids are unique considerations that arise from the relative difficulties of studying lipids and lipid-interacting proteins. These necessitate the development of competent shared facilities and collaborative efforts to bring various disciplines and expertise to bear on specific problems. Therefore, the strategic focus of the next phase is to achieve the development of a stand-alone Center of Lipidomics and Pathobiology at MUSC that will build on these remarkable scientific and institutional achievements and that will continue to catapult lipid research at MUSC. The overall objective is to capitalize on the exceptional strengths at MUSC in lipid biology with specific goal to: 1) define and develop specific thematic programmatic activities focusing on important pathobiology based on Center activities (e.g. cancer, neurodegeneration, metabolic disorders and infection/inflammation); 2) enhance translational research; 3) enhance mentoring to meet the increasing challenges of the current funding environment; 4) enhance the function of the cores and position them to better serve thematic and translational goals; 5) complete the development of the novel Lipidomics Portal; and 6) develop and achieve sustainability of the cores. We anticipate that these activities will result in a highly developed interdisciplinary research center with a critical mass of collaborative, independently and programmatically funded investigators in an evolving area of research of major significance to cancer biology, aging, inflammation, diabetes, neurodegeneration and infectious diseases.