EEG Patch

摘要 EEG PatchTM是一种单通道(2个电极)可穿戴式贴片 专为癫痫患者设计的长期脑电记录装置 在他们的日常环境中使用。为了最大限度地治疗癫痫， 长期捕捉脑电活动的重要日常变化是至关重要的 包括癫痫样事件的发生和持续时间的时期，例如 棘波放电和癫痫发作。有权访问更完整的 记录一个人的癫痫发作可能会改善治疗策略，以平衡 抗癫痫药物与癫痫控制的副作用。由于缺乏 对于长期的脑电数据，临床医生被迫依赖癫痫日记， 自我报告缉获量的方法已被证明是不准确的 往往具有误导性，仅仅因为这个人没有意识到他们已经 癫痫发作。一种不显眼的、在家的、每周一次的脑电监测设备 对癫痫发作的计数，可能会彻底改变临床诊断和治疗 为癫痫患者采取的行动。EEG贴片设计用于 在传统的EEG确定癫痫发作的开始或泛化之后 至于当癫痫发作时提供记录的最佳位置(S) (计算癫痫发作次数)。目前还没有设备可以提供EPitel的EEG PatchTM|Long- 临床医生对一个人的癫痫发作进行长期量化报告，记录癫痫发作的长期脑电 适用于日常使用的日常环境中的居家监控。 不是基于日记的。 埃皮特尔将在脑电长期监测单位的脑电贴片的第一阶段可行性研究中解决这一需求 要解决特定的启用临床能力，请执行以下操作： 一种位置准确的单通道脑电贴片可以用来计算癫痫发作的准确率，就像“黄金-- 标准“有线脑电” 埃皮特尔已经开发出其功能原型EEG Patch，一种 无线1通道(2电极)差分放大发射机 和数据记录仪，能够记录7天的脑电。脑电波 Patch消耗1.14 mA(3.42 mW)，由单个 锂一次电池(CR2330,265毫安)。独一无二的健壮 设计将为用户在日常活动中提供完整的移动性，脑电贴片不显眼，放置在 例如，在脑电监测期间洗澡、运动和睡眠，对于癫痫专家来说，头皮上的关键问题是 供病人领养。在记录了一周后，EEG贴片出现了癫痫发作。电极，电极 返回到EPitel，其中EEG活动的个性化报告将遵循标准的高密度 提供给用户和用户的癫痫专家。有线脑电波。 癫痫长期监测单元中EPitel单通道脑电贴片的癫痫记录 科罗拉多大学。痕迹是作为标准护理入院进行视频脑电监测的患者的脑电。 脑电贴片被放置在有线电极之间，癫痫发作通过全蒙太奇检查得到证实。 通往脑电贴片商业化的大门将表明，1通道、2电极设备可以 记录特定位置的癫痫数据以及长达7天的黄金标准有线EEG。长期目标 是让脑电贴片成为“在家”癫痫发作报告(计数)的标准。脑电的简单性 补丁使获取更完整、更定量的EEG记录更容易，该记录识别患者的病史 癫痫发作比自我报告更准确。EEG贴片可以改善患者与医生的互动 可以使癫痫的个性化治疗发生深刻的变化。

ABSTRACT The EEG PatchTM is a single channel, (2 electrode) wearable, patch-like device designed for long-term, EEG recording in people with epilepsy to be used in their everyday environment. To maximize the treatment of epilepsy, it is critical to capture important day-to-day changes in EEG activity for long periods including the occurrence and duration of epileptiform events such as spike-wave discharges and seizures. Having access to a more complete record of a person’s seizures may improve the treatment strategy to balance the side-effects of anti-seizure medication with seizure control. Due to a lack of long-term EEG data, clinicians are forced to rely on seizure diaries, a method of self-reporting seizures that has been shown to be inaccurate and often misleading, simply because the person does not realize they have had a seizure. An unobtrusive, at-home, weekly EEG monitoring device capable of counting seizures, could revolutionize clinical diagnoses and therapeutic actions for people living with epilepsy. The EEG Patch is designed to be used after traditional EEG has determined where seizures begin or generalize so as to provide the optimal location(s) for recording when seizures occur (seizure counting). There is currently no device that can provide Epitel’s EEG PatchTM | Long- clinicians with a long-term quantitative report of a person’s seizures term EEG recording of seizure suitable for at-home monitoring in their everyday environment that is occurrence for everyday use. not diary-based. Epitel will address this need in a Phase I feasibility study of the EEG Patch in the EEG long-term monitoring unit to address a specific enabling clinical capability:  A well-placed, single-channel EEG Patch can be used to count seizures just as accurately as the "gold- standard" wired EEG Epitel has developed its functional prototype EEG Patch, a wireless 1 channel (2 electrode) differentially amplified transmitter and data logger, capable of recording EEG for 7 days. The EEG Patch draws 1.14 mA (3.42 mW) and is powered by a single lithium primary battery (CR2330, 265 mAh). The unique robust design will provide users with complete mobility in daily activities The EEG Patch is unobtrusive and placed such as bathing, sports, and sleep during EEG monitoring, critical on the scalp by an epileptologist where for patient adoption. After a week of recording, the EEG Patch is seizures are known to manifest. Electrode returned to Epitel where a personalized report of EEG activity will spacing follows standard high-density be provided to both the user and the user’s epileptologist. wired EEG. Seizure recording from Epitel’s single-channel EEG Patch in the epilepsy long-term monitoring unit at the University of Colorado. Traces are EEG from a patient admitted for video-EEG monitoring as standard-of-care. The EEG Patch was placed between wired electrodes and the seizure verified with full-montage review. The gateway to commercialization of the EEG Patch will be showing that a 1-channel, 2-electrode device can record location-specific seizure data as well as the gold standard wired EEG for up to 7 days. The long-term goal is for the EEG Patch to become the ‘at-home’ seizure reporting (counting) standard. The simplicity of the EEG Patch makes it easier to obtain a more complete, quantitative EEG record that identifies a history of a patient’s seizures with more accuracy than self-reporting. The EEG Patch could improve patient-physician interaction that could make a profound change in the personalized treatment of epilepsy.