Core Grant for Vision Research

总结 我们的中心核心的总体目标是提供专业知识，设施和设备，以促进和扩大 威斯康星大学麦迪逊分校的视觉研究。这将由四个核心来完成。矢量 和基因递送/定量分子生物学核心将促进基因递送方法的使用，qPCR 和其他分子方法。病理学和成像核心将有助于使用共聚焦 显微镜、荧光和光学显微镜、组织病理学、专门的组织染色方法和图像 核心用户分析。动物模型和器官培养核心将促进使用非人类 灵长类、啮齿类等动物眼病模型，利用OCT、ERG、VEP评估视觉 功能，以及使用其他视觉结构和功能结果测量。生物统计学和 流行病学资源核心将促进适当的研究设计、功效计算的使用、 重要性的统计测量，以及核心用户的适当数据分析方法。

SUMMARY The overall goal of our Center Core is to provide expertise, facilities, and equipment to foster and expand vision research at the University of Wisconsin-Madison. This will be accomplished by four Cores. The Vector and Gene Delivery/Quantitative Molecular Biology Core will facilitate the use of gene delivery methods, qPCR and other molecular methods by core users. The Pathology and Imaging Core will facilitate the use of confocal microscopy, fluorescent and light microscopy, histopathology, specialized tissue staining methods, and image analysis by core users. The Animal Models and Organ Culture Core will facilitate the use of non-human primate, rodent and other animal models of ocular disease, the use of OCT, ERG, VEP to assess visual function, and the use of other visual structure and function outcome measures. The Biostatistics and Epidemiology Resource Core will facilitate proper study designs, the use of power calculations, proper use of statistical measures of significance, and proper data analysis methods for Core users.