Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health Study

女性癌症的长期多学科研究：护士健康研究

• 批准号: 9099795
• 负责人: Meir Stampfer
• 金额: $ 293.65万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-22 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9099795
• 关键词: Address; Age; Aging; Archives; Behavior; Behavioral; Behavioral Genetics; Big Data; Biological Markers; Blood; Blood specimen; Body mass index; Cancer Etiology; Cancer Patient; Cancer Survivor; Cells; Collection; Colorectal Cancer; Complement; Complex; Computer software; DNA; Data; Data Analyses; Data Sources; Development; Diagnosis; Diagnostic; Environment; Etiology; Film; Future; Genomics; Goals; Health; Health Policy; Incidence; Institute of Medicine (U.S.); Investments; Leadership; Life Style; Malignant Neoplasms; Mammography; Measurement; Measures; Medicare; Medicare claim; Mental Health; Methods; Morbidity - disease rate; Nurses' Health Study; Ovarian; Participant; Pathway interactions; Physical Function; Physical activity; Pilot Projects; Plasma; Positioning Attribute; Prevention; Preventive; Procedures; Quality of life; Questionnaires; Recurrence; Research; Research Infrastructure; Research Personnel; Research Support; Resource Sharing; Resources; Risk Factors; Sampling; Seminal; Specimen; Statistical Models; Structure; Structure of nail of toe; System; Systems Biology; Time; Tissue Banks; Tissues; Tumor Tissue; United States National Institutes of Health; Update; Urine; Woman; Work; aged; base; behavior measurement; biobank; breast density; cancer diagnosis; cancer prevention; cancer site; cancer survival; cancer therapy; cohort; cost; data management; data sharing; diagnostic screening; digital; experience; follow-up; genome wide association study; health care service utilization; health economics; improved; innovation; malignant breast neoplasm; metabolomics; middle age; mortality; multidisciplinary; novel; repository; sample collection; transcriptomics; tumor heterogeneity

DESCRIPTION (provided by applicant): This is a UIVII application to support the infrastructure of the original Nurses' Health Study (NHS). The NHS began in 1976 with 121,700 women, and has accumulated data from 19 questionnaires over 37 years; follow-up remains about 90 percent. The wealth of behavioral data combined with multiple bio-specimen collections, including blood, toenails, urine, buccal cells and tumor tissues beginning in 1.983 from a substantial proportion of women, provide an unparalleled resource in studying cancer prevention, etiology, and survival. Sustained follow-up of the NHS through repeated questionnaire mailings and continued identification of cancer incidence and mortality will permit critical new research. With the cohort's maturation (women are now 66+ years, at peak ages for cancer incidence), we propose to add emphasis to two overarching themes. First, we propose to expand the infrastructure for cancer survival research, including both the duration and quality of life in cancer patients. The many years of characterization of cancer patients before and after diagnosis, will allow us to distinguish between causes and consequences of cancer and its treatment. Second, we propose to improve our infrastructure to support a systems biology approach to our research, integrating questionnaire data with biomarkers in DNA, blood, tumor tissue, and other bio specimens; such research simultaneously integrating multiple "systems", including behavior, genomics, transcriptomics, metabolomics, etc., may illuminate new mechanisms underlying cancer. Our large and growing number of incident cancer cases, and the unique combination of questionnaires and bio specimens, are a necessity for such integrative research. Specifically, our Aims include new collection of quality of life data, new (collection of tumor tissue (resulting in tissue collections, across 17 cancer sites), improved dat management/statistical support for "big data" analyses, and enhanced infrastructure for data sharing (the NHS resource is already extensively utilized - we have provided access to >75 external investigators in the past 5-6 years and 27 NCI cancer consortia). The NHS structure combines the long experience of senior leaders with support of several developing leaders; this combination is purposeful, to maintain leadership to sustain the cohort's future. In conclusion, NHS is well-positioned to continue cutting-edge research to reduce cancer morbidity and mortality. With the previous investment from NIH and investigators, the incremental costs of continuing this cohort are modest in relation to the uniquely valuable findings that will emerge in the coming 5 years. RELEVANCE: This UMI application is to extend follow-up of the original Nurses' Health Study, with extensive data on health, and lifestyle, integrated with biologic data (e.g., genomics, plasma biomarkers, tumor tissue, etc.), enabling novel research on cancer etiology, prevention and survival. No other cohort of comparable size includes such long follow-up with repeated behavioral measures, and bio specimens from 82,000 women. This enables studies of the time frame for causal and preventive factors for cancer etiology and survival.

描述（由申请人提供）：这是一个 UIVII 应用程序，用于支持原始护士健康研究 (NHS) 的基础设施。 NHS 始于 1976 年，共有 121,700 名女性参与，37 年来通过 19 份问卷调查积累了数据；随访率仍保持在 90% 左右。大量的行为数据与多种生物样本采集相结合，包括自 1.983 年以来大部分女性的血液、脚趾甲、尿液、口腔细胞和肿瘤组织，为研究癌症预防、病因学和生存提供了无与伦比的资源。通过重复邮寄问卷和持续确定癌症发病率和死亡率，NHS 的持续跟踪将有助于进行重要的新研究。随着群体的成熟（女性现在已经 66 岁以上，处于癌症发病的高峰年龄），我们建议重点关注两个总体主题。首先，我们建议扩大癌症生存研究的基础设施，包括癌症患者的生活持续时间和质量。多年来对癌症患者诊断前后的特征分析，将使我们能够区分癌症及其治疗的原因和后果。其次，我们建议改善我们的基础设施，以支持我们的研究采用系统生物学方法，将问卷数据与 DNA、血液、肿瘤组织和其他生物样本中的生物标志物相结合；此类研究同时整合多个“系统”，包括行为、基因组学、转录组学、代谢组学等，可能会阐明癌症背后的新机制。我们大量且不断增加的癌症病例，以及问卷和生物标本的独特组合，是此类综合研究的必要条件。具体来说，我们的目标包括新收集生活质量数据、新收集肿瘤组织（收集 17 个癌症部位的组织）、改进数据管理/对“大数据”分析的统计支持，以及增强数据共享基础设施（NHS 资源已得到广泛利用 - 我们在过去 5-6 年中为超过 75 名外部研究人员和 27 个 NCI 癌症联盟提供了访问权限）。 将高级领导者的长期经验与几位发展中领导者的支持相结合；这种组合是有目的的，旨在保持领导地位，维持团队的未来。总之，NHS 处于有利位置，可以继续开展前沿研究，以降低癌症发病率和死亡率。凭借 NIH 和研究人员之前的投资，继续这一队列的增量成本相对于将出现的独特有价值的发现而言是适度的。 未来5年。 相关性：该 UMI 应用程序旨在扩展原始护士健康研究的后续工作，提供有关健康和生活方式的广泛数据，并与生物数据（例如基因组学、血浆生物标志物、肿瘤组织等）相结合，从而实现癌症病因学、预防和生存方面的新颖研究。没有其他规模可比的队列包括如此长时间的重复行为测量随访以及来自 82,000 名女性的生物样本。这使得研究癌症病因和生存的因果和预防因素的时间范围成为可能。