A New Era of Targeted Drug Discovery and the Path of Development: From Molecular

靶向药物发现的新时代及发展路径：从分子开始

基本信息

批准号：
9081581
负责人：
Gabrielle Gold-von Simson
金额：
$ 9.44万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-07-01 至 2018-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9081581
关键词：
Achievement Address Advisory Committees Americas Area Assessment tool Back Basic Science Behavioral Research Belief Biomedical Research Breathing Businesses Capital Cardiovascular Diseases Case Study Clinical Research Clinical Trials Collaborations Complications of Diabetes Mellitus Cost Analysis Data Development Diabesity Diabetes Mellitus Diabetic Nephropathy Discipline Disease Doctor of Philosophy Drug Monitoring Economics Educational Activities Educational Curriculum Educational Status Educational process of instructing Ensure Ethics Evaluation Faculty Faculty Workshop Failure Future Goals Grant Health Health Policy Individual Industry Investments Knowledge Legal patent Logistics Manuscripts Marketing Mission Molecular National Institute of Diabetes and Digestive and Kidney Diseases Natural regeneration Nature Obesity Outcome Measure Participant Pathway interactions Patient Care Patient Self-Report Patients Performance Pharmaceutical Preparations Pharmacologic Substance Phase Press Releases Process Public Health Public Opinion Qualitative Evaluations Quantitative Evaluations Recommendation Regulation Reporting Research Research Infrastructure Research Personnel Resources Retinal Diseases Rewards Running Safety Schools Scientist Series Shapes Signal Pathway Signal Transduction Specific qualifier value Stimulus Students Surveys Task Performances Technology Therapeutic Therapeutic Intervention Training Translating Translational Research United States National Institutes of Health Work Writing base bench to bedside course implementation curriculum development curriculum enhancement design drug development drug discovery experience falls follow-up health practice improved improved outcome innovation interest meetings multidisciplinary new therapeutic target news novel post-market programs research and development skills success tool

项目摘要

DESCRIPTION (provided by applicant): We propose to modify a series of courses into a highly relevant NIDDK educational activity. {Despite promising clinical studies in patients with diabetic complications, such as diabetic nephropathy, retinopathy and cardiovascular disease as examples, pharmaceutical companies have been reluctant to pursue drug development in this important area. NIDDK has duly stepped in with several initiatives to support research and drug development for diabetic complications. As such, our ultimate goal will be to teach a diverse group of targeted learners at the graduate level and beyond} to harness novel bench-to-bedside empirical knowledge in their research {and related endeavors} with a focus on diabetes, {diabetic complications}, and obesity, specific, comorbid, and pervasive public health problems. {We will highlight the importance of designing therapeutic interventions based on target changes during the disease; for example, some targets may be more relevant in initiation, others more in progression, and some more in failure of regression and regeneration.} The programmatic theme that emphasizes translation of research discoveries to patient care will be drug discovery and development. The current yearlong course series reviews Phase I-IV trials, post- marketing trajectories, safety monitoring, drug patents, and economic stimulus reform as well as ethics and cost analysis in the fall semester. In the spring semester, the molecular pathways and scientific basis of successful and unsuccessful drugs are discussed. Our preliminary experience has established that together, the two course segments (and ongoing didactic seminar series) help to disabuse the limiting belief that individuals cannot directly work towards inventing drugs, and the educational activity directs the diverse interests of this wide range of trainees towards the inspirations and rewards of translating basic science discoveries into useful patient care tools. Qualitative and quantitative reporting tools and performance tasks will evaluate the program to assure achievement of educational goals as well as future expansion of the program. Progress in achieving these objectives would mean increased NIDDK-relevant translational research skills for the diverse participants to ultimately improve patient care and public health.

描述（由申请人提供）：我们建议将一系列课程修改为高度相关的NIDDK教育活动。 {尽管在患有糖尿病并发症患者的临床研究中，例如糖尿病性肾病，视网膜病和心血管疾病为例，药物公司仍然不愿在这一重要领域进行药物开发。 NIDDK已正式介入了几项倡议，以支持糖尿病并发症的研究和药物开发。因此，我们的最终目标将是在研究生层面及以后的一群有针对性的学习者}在他们的研究中以糖尿病为重点，{及其相关的努力}在他们的研究中，以糖尿病，{糖尿病并发症}的重点，{糖尿病并发症}和厄劳斯，特定的，富有的，富有的公共健康问题。 {我们将强调基于疾病期间目标变化设计治疗干预措施的重要性；例如，某些目标可能在启动中更相关，其他目标在进步方面更重要，而在回归和再生的失败中则更多。}强调将研究发现转换为患者护理的计划主题将是药物发现和开发。当前的一年课程系列审查了I-IV期试验，营销后轨迹，安全监控，毒品专利和经济刺激改革以及秋季学期的道德和成本分析。在春季学期，讨论了成功和失败药物的分子途径和科学基础。我们的初步经验确定，两个课程细分（以及正在进行的教学研讨会系列）有助于剥夺局限性的信念，即个人不能直接致力于发明毒品，教育活动将这些广泛的学员的各种利益引导到将基础科学发现转化为有用的患者护理工具的灵感和回报。定性和定量报告工具和绩效任务将评估该计划，以确保实现教育目标以及未来的计划扩展。实现这些目标的进展将意味着增加与NIDDK相关的翻译研究技能，以最终改善患者护理和公共卫生。