Disseminating CaST Center software and methodologies to the Research Community

项目总结 CAST外联核心计划将产生明显的结果，促进和激励我们的调查人员， 我们的科学，我们的社区。它的使命将通过支持CAST研究的目标来完成： 首先，将协调梦想挑战，以鼓励社区范围内对小说的创新分析 由CAST生成的数据集。癌症系统生物学推断细胞成分相互作用的网络 来自下一代生物数据。然而，与生成的数据的质量和类型有关的问题 需要以系统和不偏不倚的方式解决算法的预测效果。对话 逆向工程评估和方法(DREAM)计划(由Califano博士共同创立)是 是为此目的而设计的，是开放科学、众包挑战领域的老牌领导者。 其次，CAST调查人员将参与有组织的、深入的机会，学习新的、互补的 与CAST目标相关的技能。这种交叉培训将使调查人员能够更全面地思考和 对他们的研究持批评态度。更大规模的交叉培训计划将在哥伦比亚全境建立， 并将与其他CSBC中心进行人员交流。为哥伦比亚大学举办的为期一天的年度研讨会 生物医学社区将与精密医学倡议合作提供。 第三，纽约科学院的系统生物学讨论小组，该小组 由Califano博士建立，将转变为CSBC研讨会/讨论系列。这些一年两次的活动 将向科学界开放，并将由主题演讲组成，然后是闭门的、有重点的 调查会议，以解决与在一般性会议上介绍的科学有关的知识和技术差距 开会。在每一次活动中，来自另一个CSBC中心的一名高级调查员将被邀请作为主要演讲人 并在中国科协担任短期客座科学家。 第四，将通过一个中心网站(网络广播)、一份季刊时事通讯、 年度报告和社区活动。为了实现CAST产品的广泛共享，CAST 将使用Biositemaps编辑器对软件和数据资源进行注释和发布。生物专题地图是一种 来自NIH国家生物医学计算中心的机制，用于开放广播和检索Meta- 有关生物医学资源的数据。此外，通过CAST学者计划，CAST人员将瞄准， 培训和指导来自代表性不足群体的初出茅庐的科学家。每年夏天，两名本科生实习生 来自纽约市立大学(CUNY)系统的学院将主办，每年在 职业女性将被邀请成为指导对象，通过CAST与科学家的参与 基金会。让学生在职业生涯早期就进入跨学科的学术/研究环境是 激励下一代癌症系统生物学研究人员的有效机制。

PROJECT SUMMARY The CaST Outreach Core program will produce palpable outcomes that foster and invigorate our investigators, our science, and our communities. Its mission will be accomplished through aims to support CaST research: First, DREAM challenges will be coordinated to encourage community-wide, innovative analysis of the novel datasets produced by CaST. Cancer systems biology infers networks of interactions of cellular components from next-generation biological data. However, issues related to the quality and types of data generated and to the predictive efficacy of the algorithms need to be addressed in systematic and unbiased ways. The Dialogue for Reverse Engineering Assessments and Methods (DREAM) program (co-founded by Dr. Califano) was designed for this purpose and is an established leader in open science, crowdsourcing challenges. Second, CaST investigators will participate in structured, in-depth opportunities to learn new, complementary skills related to CaST objectives. Such cross-training will allow investigators to think more holistically and critically about their research. Larger-scale cross-training programs will be established throughout Columbia, and personnel will be exchanged with other CSBC centers. An annual one-day workshop for the Columbia biomedical community will be offered in collaboration with the Precision Medicine Initiative. Third, the Systems Biology Discussion Group at the New York Academy of Sciences (NYAS), which was established by Dr. Califano, will be transformed into a CSBC seminar/discussion series. These biannual events will be open to the scientific community and will consist of thematic talks, followed by a closed-door, focused inquiry session to address the knowledge and technology gaps related to the science presented at the general meeting. At each event, a senior investigator from another CSBC center will be invited as the key note speaker and as a short-term visiting scientist at CaST. Fourth, CaST information will be disseminated through a center website (Web CaST), a quarterly newsletter, a yearly report, and community-based activities. To enable the wide-spread sharing of CaST's products, CaST software and data resources will be annotated and published using the Biositemaps Editor. Biositemaps is a mechanism from the NIH National Centers of Biomedical Computing for open broadcast and retrieval of meta- data about biomedical resources. In addition, through the CaST Scholars program, CaST personnel will target, train, and mentor budding scientists from underrepresented groups. Each summer, two undergraduate interns from the Colleges of the City University of New York (CUNY) system will be hosted, and, each year, pre- professional women will be invited to become mentees through CaST's involvement with the Scientista Foundation. Involving students in an interdisciplinary academic/research environment early in their careers is an effective mechanism to inspire the next generation of cancer systems biology researchers.