Disseminating CaST Center software and methodologies to the Research Community

向研究界传播 CaST 中心软件和方法

• 批准号: 9186389
• 负责人: DIANA MURRAY
• 金额: $ 19.75万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-08 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9186389
• 关键词: Academy; Address; Advisory Committees; Algorithms; Area; Behavior; Biological; Biomedical Computing; Cities; Clinical; Collaborations; Communities; Computer software; Data; Data Set; Drug Combinations; Educational workshop; Engineering; Environment; Event; Faculty; Fostering; Foundations; Generations; Human Resources; Internet; Internships; Knowledge; Learning; Malignant Neoplasms; Mentors; Metadata; Methodology; Methods; Mind; Mission; NCI Scholars Program; New York; New York City; Newsletter; Outcome; Palpable; Plants; Precision Medicine Initiative; Publishing; Recruitment Activity; Reporting; Research; Research Personnel; Resources; Retrieval; Schools; Science; Scientist; Second Primary Cancers; Seeds; Series; Staging; Structure; Students; System; Systems Biology; Technology; Therapeutic; Therapeutic Human Experimentation; Thinking; Time; Training; Training Programs; Underrepresented Groups; United States National Institutes of Health; Universities; Visit; Woman; base; biomedical resource; career; college; community center; computer science; crowdsourcing; design; innovation; insight; interest; investigator training; meetings; next generation; novel; novel strategies; open data; outreach; outreach program; programs; skills; tumor; web site; young woman

PROJECT SUMMARY The CaST Outreach Core program will produce palpable outcomes that foster and invigorate our investigators, our science, and our communities. Its mission will be accomplished through aims to support CaST research: First, DREAM challenges will be coordinated to encourage community-wide, innovative analysis of the novel datasets produced by CaST. Cancer systems biology infers networks of interactions of cellular components from next-generation biological data. However, issues related to the quality and types of data generated and to the predictive efficacy of the algorithms need to be addressed in systematic and unbiased ways. The Dialogue for Reverse Engineering Assessments and Methods (DREAM) program (co-founded by Dr. Califano) was designed for this purpose and is an established leader in open science, crowdsourcing challenges. Second, CaST investigators will participate in structured, in-depth opportunities to learn new, complementary skills related to CaST objectives. Such cross-training will allow investigators to think more holistically and critically about their research. Larger-scale cross-training programs will be established throughout Columbia, and personnel will be exchanged with other CSBC centers. An annual one-day workshop for the Columbia biomedical community will be offered in collaboration with the Precision Medicine Initiative. Third, the Systems Biology Discussion Group at the New York Academy of Sciences (NYAS), which was established by Dr. Califano, will be transformed into a CSBC seminar/discussion series. These biannual events will be open to the scientific community and will consist of thematic talks, followed by a closed-door, focused inquiry session to address the knowledge and technology gaps related to the science presented at the general meeting. At each event, a senior investigator from another CSBC center will be invited as the key note speaker and as a short-term visiting scientist at CaST. Fourth, CaST information will be disseminated through a center website (Web CaST), a quarterly newsletter, a yearly report, and community-based activities. To enable the wide-spread sharing of CaST's products, CaST software and data resources will be annotated and published using the Biositemaps Editor. Biositemaps is a mechanism from the NIH National Centers of Biomedical Computing for open broadcast and retrieval of meta- data about biomedical resources. In addition, through the CaST Scholars program, CaST personnel will target, train, and mentor budding scientists from underrepresented groups. Each summer, two undergraduate interns from the Colleges of the City University of New York (CUNY) system will be hosted, and, each year, pre- professional women will be invited to become mentees through CaST's involvement with the Scientista Foundation. Involving students in an interdisciplinary academic/research environment early in their careers is an effective mechanism to inspire the next generation of cancer systems biology researchers.

项目摘要 演员外展核心计划将产生明显的成果，以促进和激发我们的调查人员， 我们的科学和我们的社区。它的使命将通过支持演员研究的目标来完成： 首先，梦想挑战将得到协调，以鼓励对小说的社区范围内的创新分析 Cast生产的数据集。癌症系统生物学渗透了细胞成分相互作用网络 从下一代生物学数据。但是，与生成数据的质量和类型相关的问题以及 算法的预测功效需要以系统的和公正的方式解决。对话 用于逆向工程评估和方法（Dream）计划（由Califano博士共同创立）是 为此目的而设计，是开放科学领域的既定领导者，众包挑战。 其次，演员调查人员将参加结构化的，深入的学习新的，互补的 与演员目标有关的技能。这种交叉训练将使调查人员能够更全面地思考 关于他们的研究至关重要。将在整个哥伦比亚建立大规模的跨训练计划 人员将与其他CSBC中心交换。哥伦比亚的年度一日研讨会 生物医学界将与Precision Medicine Initiative合作提供。 第三，纽约科学院（NYAS）的系统生物学讨论小组 由Califano博士建立的将转变为CSBC研讨会/讨论系列。这些双年度事件 将向科学界开放，并将由主题谈判组成，然后是关注的封闭式演讲 询问会议以解决与一般科学相关的知识和技术差距 会议。在每个活动中，将邀请另一个CSBC中心的高级调查员作为关键音符发言人 作为Cast的短期来访科学家。 第四，演员信息将通过中心网站（网络演员），季度新闻通讯，一个， 年度报告和基于社区的活动。为了启用演员产品的广泛分享， 软件和数据资源将使用BioSitemaps编辑器注释和发布。生物群是一个 NIH国家生物医学计算中心的机制，用于开放广播和检索 有关生物医学资源的数据。此外，通过演员学者计划，演员人员将针对 训练和来自代表性不足的团体的导师崭露头角的科学家。每年夏天，两个本科实习生 纽约城市大学（CUNY）系统将被托管，并且每年都会预先 通过演员的参与，将邀请职业女性成为受训者 基础。让学生在职业生涯的早期参与跨学科的学术/研究环境是 激发下一代癌症系统生物学研究人员的有效机制。