Disseminating CaST Center software and methodologies to the Research Community

项目摘要 CastOutreach Core计划将产生明显的成果，促进和激励我们的调查人员， 我们的科学，我们的社区其使命将通过支持CAST研究的目标来实现： 首先，梦想的挑战将协调，以鼓励社区范围内，创新的小说分析 由Casts制作。癌症系统生物学推断细胞成分相互作用的网络 从下一代生物数据中。然而，与所生成数据的质量和类型以及 算法的预测功效需要以系统和无偏的方式来解决。对话 逆向工程评估和方法（DREAM）计划（由Califano博士共同创立） 为此目的而设计，是开放科学、众包挑战的公认领导者。 其次，Casts调查人员将参加结构化的深入机会，以学习新的，互补的 与CAST目标相关的技能。这种交叉培训将使调查人员能够更全面地思考， 批评他们的研究。将在整个哥伦比亚建立更大规模的交叉培训项目， 并将与CSBC其他中心进行人员交流。哥伦比亚号的年度一天研讨会 生物医学社区将与精准医学倡议合作提供。 第三，纽约科学院（NYAS）的系统生物学讨论组， 由Califano博士建立的研讨会将转变为CSBC研讨会/讨论系列。这些一年两次的活动 将向科学界开放，将包括主题会谈，然后是闭门会议， 讨论会上提出的与科学有关的知识和技术差距 会议在每次活动中，将邀请来自另一个CSBC中心的高级研究员作为主要发言人 并在卡斯特做短期访问科学家 第四，将通过一个中心网站（Web CAST）、一份季度通讯、一份 年度报告和社区活动。为了让更多的人能够分享Casts的产品，Casts 软件和数据资源将使用Biositemaps编辑器进行注释和发布。Biositemaps是一个 来自NIH国家生物医学计算中心的机制，用于公开广播和检索Meta， 生物医学资源的数据。此外，通过卡斯特学者计划，卡斯特人员将针对， 培训和指导来自代表性不足群体的初露头角的科学家。每年夏天，两名本科实习生 来自纽约（CUNY）系统的学院将被托管，并且，每年， 职业女性将被邀请成为学员通过卡斯特的参与与科学家 基金会让学生在职业生涯早期参与跨学科的学术/研究环境， 这是一种有效的机制，可以激励下一代癌症系统生物学研究人员。

PROJECT SUMMARY The CaST Outreach Core program will produce palpable outcomes that foster and invigorate our investigators, our science, and our communities. Its mission will be accomplished through aims to support CaST research: First, DREAM challenges will be coordinated to encourage community-wide, innovative analysis of the novel datasets produced by CaST. Cancer systems biology infers networks of interactions of cellular components from next-generation biological data. However, issues related to the quality and types of data generated and to the predictive efficacy of the algorithms need to be addressed in systematic and unbiased ways. The Dialogue for Reverse Engineering Assessments and Methods (DREAM) program (co-founded by Dr. Califano) was designed for this purpose and is an established leader in open science, crowdsourcing challenges. Second, CaST investigators will participate in structured, in-depth opportunities to learn new, complementary skills related to CaST objectives. Such cross-training will allow investigators to think more holistically and critically about their research. Larger-scale cross-training programs will be established throughout Columbia, and personnel will be exchanged with other CSBC centers. An annual one-day workshop for the Columbia biomedical community will be offered in collaboration with the Precision Medicine Initiative. Third, the Systems Biology Discussion Group at the New York Academy of Sciences (NYAS), which was established by Dr. Califano, will be transformed into a CSBC seminar/discussion series. These biannual events will be open to the scientific community and will consist of thematic talks, followed by a closed-door, focused inquiry session to address the knowledge and technology gaps related to the science presented at the general meeting. At each event, a senior investigator from another CSBC center will be invited as the key note speaker and as a short-term visiting scientist at CaST. Fourth, CaST information will be disseminated through a center website (Web CaST), a quarterly newsletter, a yearly report, and community-based activities. To enable the wide-spread sharing of CaST's products, CaST software and data resources will be annotated and published using the Biositemaps Editor. Biositemaps is a mechanism from the NIH National Centers of Biomedical Computing for open broadcast and retrieval of meta- data about biomedical resources. In addition, through the CaST Scholars program, CaST personnel will target, train, and mentor budding scientists from underrepresented groups. Each summer, two undergraduate interns from the Colleges of the City University of New York (CUNY) system will be hosted, and, each year, pre- professional women will be invited to become mentees through CaST's involvement with the Scientista Foundation. Involving students in an interdisciplinary academic/research environment early in their careers is an effective mechanism to inspire the next generation of cancer systems biology researchers.