权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Noninvasive fragmentation of urinary calculi with focused ultrasound bursts

聚焦超声脉冲无创碎裂泌尿系结石

基本信息

批准号：
9069839
负责人：
Adam Douglas Maxwell
金额：
$ 13.7万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-06-01 至 2020-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9069839
关键词：
Acoustics Adopted Affect Area Attention Biomedical Engineering Characteristics Clinical Clinical Treatment Data Development Devices Disease Exposure to Family suidae Feedback Focused Ultrasound Focused Ultrasound Therapy Fracture Frequencies Generations Goals Health Healthcare Histology In Vitro Individual Injury Injury to Kidney Institution Investigation K-Series Research Career Programs Kidney Kidney Calculi Laboratories Lead Lithotripsy Measurement Measures Mechanics Mentors Methods Modeling Outpatients Output Patients Percutaneous Nephrolithotomy Physics Physiologic pulse Procedures Research Research Personnel Resources Retreatment Science Shock Source Staging Stress Surface Technology Tissues Transducers Translating Treatment Protocols Ultrasonic Therapy Ultrasonic Transducer Ultrasonography Universities Ureteroscopy Urinary Calculi Urology Washington Width Work base career development common treatment design experience improved in vivo novel novel strategies pressure prototype research and development research study standard of care success systems research technology development urolithiasis urologic

项目摘要

DESCRIPTION (provided by applicant): The candidate of the proposed Career Development Award is Dr. Adam Maxwell, a biomedical engineer with over 10 years of experience in medical ultrasound research, particularly shock wave lithotripsy and high- intensity focused ultrasound therapy. He has investigated physical interactions of acoustic waves with tissues, developed research and clinical prototype systems, and researched new applications for ultrasound therapies. The purpose of applying for this Career Development Award is for Dr. Maxwell to cultivate the qualities and abilities necessary to be a successful independent researcher and obtain expertise in urolithiasis under the guidance of three experienced mentors, Drs. Michael Bailey, Jonathan Harper, and Hunter Wessells. The University of Washington is a leading research institution at which Dr. Maxwell plans to pursue his research and career development. He will be supported by a collaborative team with expertise in stone management within the Department of Urology and medical ultrasound in the Center for Industrial and Medical Ultrasound at the Applied Physics Laboratory. His proposed research will investigate a potential new treatment for urolithiasis. Urolithiasis is a common disease that affects approximately 1 in 11 individuals during their lifetime and presents a large burden on U.S. healthcare resources. In the last 30 years, management of urinary tract stones has seen the introduction of several novel approaches, including shock wave lithotripsy (SWL), ureteroscopy, and percutaneous nephrolithotomy. SWL is the only noninvasive procedure for stones, but the likelihood of rendering patients stone-free in a single session is considerably lower than other methods, and has declined in newer lithotripters. Development of a more effective lithotripter remains an unmet clinical challenge. While the physical interactions between shocks and stones were not well understood during this technology's clinical introduction, recent research has established the mechanisms of stone fracture in SWL. Based on this work, a novel type of lithotripsy using widely focused bursts of ultrasound rather than shock waves is proposed. Preliminary data shows that burst wave lithotripsy (BWL) is capable of disintegrating stones in as little as 10 seconds. Furthermore, the size of fragments generated during the procedure can be controlled by the ultrasound frequency, potentiating a therapy that produces small fragments easily passed by patients. The goal of this proposal is to create a scientific rationale that will guide the development of burst wave lithotripsy. In particular, this project proposes to investigate the physical interactions of ultrasound bursts with stones and tissue, and use this information to determine therapy parameters. The specific aims of the proposal are: 1) Develop and characterize a suitable ultrasound source for BWL research, 2) Determine the mechanistic interactions leading to stone fracture by BWL, and 3) Identify the mechanical effects of BWL leading to tissue damage. Dr. Maxwell's long-term research goal is to translate this technology into a clinically useful treatment that improves the standard of care for stone management.