Duke - UNC Clinical Hematology and Transfusion Research Career Development Progra

描述（由申请人提供）：杜克大学医学中心（Duke）和北卡罗来纳大学教堂山分校（UNC）共同提出我们的临床血液学和输血医学研究职业发展计划的竞争更新，以响应国家心脏，肺和血液研究所RFA-HL-12-005。杜克大学和北卡罗来纳大学在血液学基础和临床研究方面有着悠久的合作传统。我们现在建议继续我们的项目，在四个临床研究重点领域培养学者，这些领域是我们医疗中心已经建立的优势，即：(1)镰状细胞病；(2)血栓形成和血栓形成；(3)止血障碍；输血医学、贫血和干细胞治疗。因此，本申请的目的是通过为致力于血液学和输血医学学术临床研究事业的学者提供临床、教学和体验项目，确保杜克大学和北卡罗来纳大学继续进行高质量的以患者为导向的研究培训。这个K12职业发展计划将包括教学和临床课程，旨在教授学者进行临床研究所需的广泛技能，并在血液学或输血医学领域建立成功的学术研究事业。每位学者都将有机会获得临床研究硕士学位，并且在基因组学和遗传学方面也有广泛的课程提供。此外，我们提出了四个主要的研究轨道，我们的学员可以进入他们的指导研究经验。每个项目至少有两名首席导师，杜克大学和北卡罗来纳大学的许多教师将担任联合导师。我们的四个方向是：(1)转化研究；(2)遗传学和药物遗传学；(3)临床试验；(4)卫生服务研究/成果/卫生政策。这种临床和教学培训的结合以及多学科指导的研究经验将为学者提交他们正在进行的研究项目的校外资助申请和他们研究生涯的成功谈判做好准备。该项目的长期目标是帮助确保训练有素的研究人员的充足供应，他们将能够通过精心设计，熟练实施和多学科临床研究来面对血液学和输血医学的临床问题。

DESCRIPTION (provided by applicant): Duke University Medical Center (Duke) and the University of North Carolina at Chapel Hill (UNC) jointly propose this competing renewal of our Clinical Hematology and Transfusion Medicine Research Career Development Program in response to the National Heart, Lung and Blood Institute RFA-HL-12-005. Duke and UNC have long traditions of collaborative basic and clinical research in hematology. We now propose to continue our program to train scholars in four Clinical Research Focus Areas that are well established strengths of our medical center, namely: (1) Sickle Cell Disease; (2) Thrombosis and Thrombophilia; (3) Disorders of Hemostasis; and (4) Transfusion Medicine, Anemia, and Stem Cell Therapy. The purpose of the present application is therefore to ensure the continuation of high quality patient-oriented research training at Duke and UNC through the provision of a clinical, didactic and experiential program for scholars who are committed to academic clinical research careers focusing on hematology and transfusion medicine. This K12 Career Development Program will include a didactic and clinical curriculum designed to teach scholars the broad array of skills needed to perform clinical research and to establish successful academic research careers in hematology or transfusion medicine. Each scholar will have the opportunity to earn a master's degree in clinical research, and there are also extensive course offerings in genomics and genetics. In addition, we propose four primary research tracks that our trainees can enter for their mentored research experience. Each has at least two Lead Mentors, and there are numerous faculty at Duke and UNC who will serve as co-mentors. Our 4 tracks are (1) Translational Research, (2) Genetics and Pharmacogenetics; (3) Clinical Trials; and (4) Health Services Research/Outcomes/Health Policy. This combination of clinical and didactic training and a multidisciplinary mentored research experience will prepare scholars for submission of applications for extramural funding for their ongoing research program and for successful negotiation of their research careers. The long-range goal of this program is thereby to help ensure an adequate supply of well trained researchers who will be able to confront the clinical problems of hematology and transfusion medicine through well-designed, skillfully conducted and multidisciplinary clinical research.