Duke-UNC Clinical Hematology Research Career Development Program

描述(由申请人提供)： 杜克大学医学中心(DUMC)和北卡罗来纳大学教堂山分校联合提出了临床血液学研究职业发展计划(K12 CHRCDP)，以响应国家心肺和血液研究所RFA-HL-06-006。杜克大学和北卡罗来纳大学在非恶性血液学的合作基础和临床研究方面有着悠久的传统。我们现在建议建立一个项目，培训非恶性血液学领域的临床研究学者，这些领域是我们医学中心公认的优势，即血红蛋白病变、止血、血栓形成和输血。因此，本申请的目的是确保杜克大学和北卡罗来纳大学以患者为中心的高质量研究培训，为致力于良性血液学学术临床研究事业的学者提供临床、教学和经验课程。 这项CHRCDP将包括教学和临床课程，旨在向学者传授进行临床研究所需的广泛技能，并在非恶性血液学领域建立成功的学术研究生涯。每位学者都将有机会获得临床研究或医学基因组学硕士学位。此外，我们提出了四个主要的研究轨道，我们的受训人员可以进入他们在非恶性血液学方面的指导研究经验。每所大学都至少有两名首席导师，杜克大学和北卡罗来纳大学的许多教职员工将担任次要导师。我们的4个项目是：(1)转译研究；(2)遗传学和药物遗传学；(3)临床试验；(4)结果/卫生政策。这种临床和教学培训的结合，以及有指导的研究经验，将为学者提交正在进行的研究计划的外部资金申请和成功谈判他们的研究生涯做好准备。因此，该计划的长期目标是帮助确保提供足够的训练有素的研究人员，他们将能够通过精心设计、熟练操作和多学科的临床研究来应对非恶性血液学的临床问题，并将熟练地将基础研究成果转化为临床实践。

DESCRIPTION (provided by applicant): Duke University Medical Center (DUMC) and the University of North Carolina at Chapel Hill jointly propose a Clinical Hematology Research Career Development Program (K12 CHRCDP) in response to the National Heart, Lung and Blood Institute RFA-HL-06-006. Duke and UNC have long traditions of collaborative basic and clinical research in non-malignant hematology. We now propose to establish a program to train scholars in clinical research in areas of non-malignant hematology that are well established strengths of our medical center, namely hemoglobinopathies, hemostasis and thrombosis and trasnsfusion. The purpose of the present application is therefore to ensure high quality patient-oriented research training at Duke and UNC through the provision of a clinical, didactic and experiential program for scholars who are committed to academic clinical research careers focusing on benign hematology. This CHRCDP will include a didactic and clinical curriculum designed to teach scholars the broad array of skills needed to perform clinical research and to establish successful academic research careers in nonmalignant hematology. Each scholar will have the opportunity to earn a master's degree in either clinical research or in medical genomics. In addition, we propose four primary research tracks that our trainees can enter for their mentored research experience in non-malignant hematology. Each has at least two Lead Mentors, and there are numerous faculty at Duke and UNC who will serve as secondary mentors. Our 4 tracks are (1) Translational Research, (2) Genetics and Pharmacogenetics; (3) Clinical Trials; and (4) Outcomes/Health Policy. This combination of clinical and didactic training and a mentored research experience will prepare scholars for submission of applications for extramural funding for their ongoing research program and for successful negotiation of their research careers. The long-range goal of this program is thereby to help ensure an adequate supply of well trained researchers who will be able to confront the clinical problems of non-malignant hematology through well-designed, skillfully conducted and multidisciplinary clinical research and who will be skilled in translating the fruits of basic research into clinical practice.