Chemistry of Biological Systems

 描述（由申请人提供）：此更新提案描述了继续开展强有力的化学-生物学接口（CBI）博士前培训计划的计划，该计划旨在为学员提供化学和生物科学交叉培训的核心背景。该计划自1996年以来一直由NIH资助，也促进了康奈尔大学校园的跨学科合作研究。每位学员将与隶属于八个参与单位的25名教师培训师中的一名或多名进行博士论文研究：化学和化学生物学，生物医学科学，化学和生物分子工程，微生物学和免疫学，分子生物学和遗传学，植物生物学，植物病理学和营养科学。参与的教师有资金充足的化学研究项目，与生物学有很强的联系，反之亦然。学生在广泛分布于化学（合成有机，生物有机，生物无机，生物物理，天然产物，X射线晶体学，代谢组学和蛋白质组学）和生物学（蛋白质结构和功能，酶学，免疫学，信号转导，趋化性，细胞生物学，宿主/病原体相互作用和基因组学）的领域接受培训。CBI继续成功地将化学和生物学的文化与有效的教学和计划举措相结合。CBI学员参加化学和生物学方面的核心严格课程，并接受负责任的研究培训。学员参加研讨会在他们的核心学科（通常每周一次），与教师一起参加一个特殊的每月CBI研讨会计划，并组织每月CBI点燃午餐和年度CBI研讨会，具有内部和外部扬声器。两个额外的功能区分康奈尔大学CBI计划：第一，每学期学员邀请，组织和主持特别研讨会发言人在化学和生物学的接口工作。其次，实习生在实验室实习，与他们的论文研究不同，通常在生物技术，生命科学或制药公司的背景下。通过这种经验，他们获得跨学科生物医学研究的经验，并接触到非学术职业。一些受训人员在实习后收到了就业机会。该计划继续产生一个高素质的学员群体，他们的背景越来越多样化，因为我们继续加强从代表性不足的群体中招募学生。重要的是，CBI培训已经实现，而不会影响在康奈尔大学完成博士学位所需的时间。在这次更新中，CBI的影响将通过扩大其范围而增加。康奈尔大学非常重视CBI在培养下一代科学家和促进跨校园合作研究方面的贡献，因此它大大增加了对该计划的机构支持，其中包括提供多达五个匹配的职位以扩大学员基础。此外，CBI的培训活动现在将成为访问谁不是由CBI计划的财政支持的学生。这些改进将加强CBI并扩大其影响。

 DESCRIPTION (provided by applicant): This renewal proposal describes plans to continue a vigorous chemistry-biology interface (CBI) predoctoral training program that is designed to provide trainees with a core background in chemistry and cross-training in biological sciences. The program, which has been continuously funded by NIH since 1996, also promotes interdisciplinary collaborative research across the Cornell Campus. Each trainee will carry out his or her doctoral thesis research with one or more of 25 faculty trainers affiliated with eight participating units: Chemistry and Chemical Biology, Biomedical Sciences, Chemical and Biomolecular Engineering, Microbiology and Immunology, Molecular Biology and Genetics, Plant Biology, Plant Pathology, and Nutritional Sciences. Participating faculty have well-funded research programs in chemistry with strong connections to biology or vice versa. Students undergo training in areas that are broadly distributed over chemistry (synthetic organic, bioorganic, bioinorganic, biophysical, natural products, X-ray crystallography, metabolomics, and proteomics) and biology (protein structure and function, enzymology, immunology, signal transduction, chemotaxis, cell biology, host/pathogen interactions, and genomics). The CBI continues to successfully merge the cultures of chemistry and biology with effective didactic and programmatic initiatives. CBI trainees take a core set of rigorous courses in both chemistry and biology and undergo responsible conduct of research training. Trainees attend seminars in their core disciplines (usually weekly), participate together with faculty in a special monthly CBI seminar program, and organize monthly CBI Lit Lunches and an annual CBI symposium that features both internal and outside speakers. Two additional features distinguish the Cornell CBI program: First, each semester trainees invite, organize, and host special seminar speakers working at the interface of chemistry and biology. Secondly, trainees intern at a laboratory distinct from that of their thesis research, usually in the context of a biotech, life science, or pharmaceutical company. Through this experience they gain experience with interdisciplinary biomedical research and are exposed to non-academic careers. Several trainees have received employment offers after their internships. The program continues to produce a high-caliber cohort of trainees, who are increasingly more diverse in their backgrounds due to our continued and intensified recruitment of students from underrepresented groups. Importantly, CBI training has been achieved without affecting the time required to complete a PhD degree at Cornell. In this renewal the impact of the CBI will be increased by expanding its scope. Cornell so values the contributions of the CBI to training the next generation of scientists and in promoting collaborative research across campus that it has dramatically increased institutional support for the program, which includes the provision of up to five matching slots to expand trainee base. In addition, the CBI training activities will now become accessible to students who are not financially supported by the CBI program. These enhancements will strengthen the CBI and broaden its impact.