Chemistry of Biological Systems

 描述(由申请人提供)：这份更新建议描述了继续一个强有力的化学-生物接口(CBI)博士前培训计划的计划，该计划旨在为受训者提供化学和生物科学交叉培训的核心背景。该项目自1996年以来一直由美国国立卫生研究院资助，还促进了康奈尔大学校园内的跨学科协作研究。每名学员将与25名教员中的一名或多名进行博士论文研究，这些教员隶属于八个参与单元：化学和化学生物学、生物医学科学、化学和生物分子工程、微生物学和免疫学、分子生物学和遗传学、植物生物学、植物病理学和营养科学。参与的教职员工有资金充足的化学研究项目，与生物学有很强的联系，反之亦然。学生在化学(合成有机、生物有机、生物无机、生物物理、天然产物、X射线结晶学、代谢组学和蛋白质组学)和生物学(蛋白质结构和功能、酶学、免疫学、信号转导、趋化作用、细胞生物学、宿主/病原体相互作用和基因组学)等领域接受培训。CBI继续成功地将化学和生物文化与有效的教学和规划举措融合在一起。CBI学员参加一套严格的化学和生物核心课程，并接受负责任的研究培训。学员参加核心学科的研讨会(通常是每周)，与教员一起参加每月CBI研讨会项目，每月组织CBI文学午餐和一年一度的CBI研讨会，有内部和外部演讲者参加。康奈尔CBI项目还有两个特点：第一，每个学期的实习生邀请、组织和主持化学和生物领域的专题研讨会演讲者。其次，实习生在与论文研究不同的实验室实习，通常是在生物技术、生命科学或制药公司的背景下实习。通过这种经历，他们获得了跨学科生物医学研究的经验，并接触到了非学术职业。一些实习生在实习结束后收到了就业机会。该计划继续培养出一批高素质的受训人员，由于我们继续并加强招收来自代表性不足群体的学生，他们的背景越来越多样化。重要的是，CBI培训在不影响康奈尔大学完成博士学位所需时间的情况下实现了。在这次更新中，CBI的影响将通过扩大其范围来增加。因此，康奈尔大学重视CBI在培训下一代科学家和促进校园内协作研究方面的贡献，因此大幅增加了对该项目的机构支持，其中包括提供最多五个匹配的名额以扩大学员基础。此外，CBI培训活动现在将向没有CBI计划经济支持的学生开放。这些改进将加强CBI并扩大其影响。

 DESCRIPTION (provided by applicant): This renewal proposal describes plans to continue a vigorous chemistry-biology interface (CBI) predoctoral training program that is designed to provide trainees with a core background in chemistry and cross-training in biological sciences. The program, which has been continuously funded by NIH since 1996, also promotes interdisciplinary collaborative research across the Cornell Campus. Each trainee will carry out his or her doctoral thesis research with one or more of 25 faculty trainers affiliated with eight participating units: Chemistry and Chemical Biology, Biomedical Sciences, Chemical and Biomolecular Engineering, Microbiology and Immunology, Molecular Biology and Genetics, Plant Biology, Plant Pathology, and Nutritional Sciences. Participating faculty have well-funded research programs in chemistry with strong connections to biology or vice versa. Students undergo training in areas that are broadly distributed over chemistry (synthetic organic, bioorganic, bioinorganic, biophysical, natural products, X-ray crystallography, metabolomics, and proteomics) and biology (protein structure and function, enzymology, immunology, signal transduction, chemotaxis, cell biology, host/pathogen interactions, and genomics). The CBI continues to successfully merge the cultures of chemistry and biology with effective didactic and programmatic initiatives. CBI trainees take a core set of rigorous courses in both chemistry and biology and undergo responsible conduct of research training. Trainees attend seminars in their core disciplines (usually weekly), participate together with faculty in a special monthly CBI seminar program, and organize monthly CBI Lit Lunches and an annual CBI symposium that features both internal and outside speakers. Two additional features distinguish the Cornell CBI program: First, each semester trainees invite, organize, and host special seminar speakers working at the interface of chemistry and biology. Secondly, trainees intern at a laboratory distinct from that of their thesis research, usually in the context of a biotech, life science, or pharmaceutical company. Through this experience they gain experience with interdisciplinary biomedical research and are exposed to non-academic careers. Several trainees have received employment offers after their internships. The program continues to produce a high-caliber cohort of trainees, who are increasingly more diverse in their backgrounds due to our continued and intensified recruitment of students from underrepresented groups. Importantly, CBI training has been achieved without affecting the time required to complete a PhD degree at Cornell. In this renewal the impact of the CBI will be increased by expanding its scope. Cornell so values the contributions of the CBI to training the next generation of scientists and in promoting collaborative research across campus that it has dramatically increased institutional support for the program, which includes the provision of up to five matching slots to expand trainee base. In addition, the CBI training activities will now become accessible to students who are not financially supported by the CBI program. These enhancements will strengthen the CBI and broaden its impact.