Chemistry of Biological Systems

描述（由申请人提供）：此更新提案描述了继续开展强有力的化学-生物学界面（CBI）博士前培训计划的计划，该计划旨在培养基础有机化学和生物化学的关键方面的科学家，以及化学和生物学界面的科学学科。该计划现已进入第十四个年头，通过将研究生学术工作集中在跨越化学和生物学科领域的核心课程上，进一步推进了我们最积极和最合格的学生的跨学科培训。每名学员可在下列十个参与单位的二十五名教员培训人员的一个或多个实验室进行博士论文研究：化学和化学生物学、植物病理学、分子生物学和遗传学、植物生物学、生物医学科学、化学和生物分子工程、微生物学和免疫学、营养科学、博伊斯·汤普森植物生物学研究所和威尔细胞和分子生物学研究所。所有参与的教师都有很强的研究项目，要么是与生物学有很强联系的化学，要么是与化学有很强联系的生物学，而且资金充足。他们的整体研究兴趣广泛分布在化学（合成有机，生物有机，生物物理，天然产物，x射线晶体学和蛋白质组学）和生物学（蛋白质结构和功能，酶学，免疫学，信号转导，趋化性，细胞生物学，宿主/病原体相互作用和遗传学）。CBI学员在各自的单位参加核心学科的研讨会（通常每周一次），与教师一起参加一个特殊的每月CBI研讨会计划，并组织每月的CBI“文学午餐”。康奈尔大学CBI项目还有两个特点。首先，学员每学期邀请、组织和主持专门的CBI研讨会演讲者。其次，受训者在与论文研究不同的实验室实习，通常是在生物技术、生命科学或制药公司。通过这种经历，他们获得了跨学科生物医学研究的接触和经验。

DESCRIPTION (provided by applicant): This renewal proposal describes plans to continue a vigorous chemistry-biology interface (CBI) predoctoral training program that is designed to train scientists in key aspects of fundamental organic and biological chemistry as well as in scientific disciplines at the interface of chemistry and biology. The program, now in its fourteenth year, further advances the interdisciplinary training of our most motivated and well-qualified students by focusing their graduate academic work around a core curriculum in areas spanning both chemical and biological disciplines. Each trainee may carry out his or her doctoral thesis research in one or more of the laboratories of the twenty-five faculty trainers affiliated with the following ten participating units: Chemistry and Chemical Biology, Plant Pathology, Molecular Biology and Genetics, Plant Biology, Biomedical Sciences, Chemical and Biomolecular Engineering, Microbiology and Immunology, Nutritional Sciences, The Boyce Thompson Institute for Plant Biology, and the Weill Institute for Cell and Molecular Biology. All participating faculty have strong research programs either in chemistry with strong biological connections or in biology with strong chemical connections and are well-funded. Their overall research interests are broadly distributed over chemistry (synthetic organic, bioorganic, biophysical, natural products, X-ray crystallography and proteomics) and biology (protein structure and function, enzymology, immunology, signal transduction, chemotaxis, cell biology, host/pathogen interactions and genetics). CBI trainees attend seminars in their core disciplines (usually weekly) in their respective units, participate together with faculty in a special monthly CBI seminar program, and organize monthly CBI "literature lunches". Two additional features distinguish the Cornell CBI program. First, trainees invite, organize, and host special CBI seminar speakers each semester. Secondly, trainees take internships in a laboratory distinct from that of their thesis research, usually in the context of a biotech, life science, or pharmaceutical company. Through this experience they gain exposure to, and experience in, interdisciplinary biomedical research.