Sterilization Improvement Grant

灭菌改进补助金

• 批准号: 9120170
• 负责人: Patrick J. Sinko
• 金额: $ 49万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-10 至 2018-08-09
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9120170
• 关键词: Affect; Animal Experimentation; Biomedical Engineering; Decontamination; Dimensions; Ensure; Equipment; Expenditure; Funding; Future; Grant; Location; Modeling; New Jersey; Pharmacy Schools; Principal Investigator; Public Health Schools; Research; Research Infrastructure; Research Personnel; Resources; Rodent; Savings; Security; Side; Sterilization; Time; United States National Institutes of Health; Universities; Wood material; animal care; biosecurity; cost; improved; medical schools; meetings; operation; square foot; trafficking

 DESCRIPTION (provided by applicant): Rutgers, The State University of New Jersey (RU)-Office of Research Advancement (ORAd) requests funds to purchase and outfit a new bulk sterilizer so current as well as future expanding numbers of rodent cages in the Research Tower (RT) Animal Care Facility (ACF) on the Busch campus in Piscataway can be efficiently and effectively sterilized. The RT currently has two sterilizers (Amsco and Steris). Although both are low profile, they are old and have significant serviceability and throughput limitations. In fact, he Amsco sterilizer is in nearly non-operable condition and must be immediately replaced. In addition, neither of the current sterilizers is able to sterilize racks. Without the requested equipment, RU Principal Investigators (PIs) will continue to be challenged to maintain existing barrier rodent colonies or expand these colonies to meet future needs. NIH-funded animal research in RT-ACF will be significantly affected. The proposed new sterilizer has more than three times the capacity of the existing Amsco sterilizer proposed for replacement and will enable significantly faster sterilization of rodent racks, cages and associated equipment than the current model. The location of this new sterilizer will also allow it to serve a dual purpose, allowing decontamination of dirty racks when loaded from the Dirty Cage Wash side while providing sterilization of clean racks when used from the Clean Cage Wash side. Replacing the existing Amsco sterilizer will also enable us to reverse the dirty and clean cage wash to improve traffic flow as well as enhance biosecurity. Additional environmental savings in resources would likewise occur with the purchase of the requested rack/cage sterilizer. Although the ACF in the nearby School of Public Health Building (SPH) has a bulk sterilizer, logistical distance, bio-security and more importantly, a heavy sterilization load at the SPH-ACF precludes the RT-ACF from sending cages to the SPH-ACF for routine sterilization. Replacing outdated, poorly functional equipment at the RT-ACF with a new bulk sterilizer will greatly enhance ORAd's ability to support current NIH-funded Robert Wood Johnson Medical School (RWJMS) investigators as well as eventually allow for a consolidation of PIs from the Schools of Pharmacy (SOP) and Biomedical Engineering (BME) to the RT-ACF. Reducing the number of satellite ACFs will greatly reduce ORAd's operating costs and reduce the per diem burden on PIs and NIH. This equipment plus 2587 square feet (SF) space and supporting infrastructure upgrade fits existing facility dimensions, and utilizes most of the existing infrastructure. To ensure equipment operation Rutgers University will pay any additional expenditure in addition to that requested in this grant. Without a new bulk sterilizer in the short term, the RT-ACF may not meet the rodent needs of RU PIs so they can properly conduct NIH funded research.

 描述（由申请人提供）：罗格斯大学新泽西州立大学 (RU) 研究推进办公室 (ORAd) 请求资金购买和装备一台新的大型灭菌器，以便对皮斯卡塔韦布希校区研究塔 (RT) 动物护理设施 (ACF) 中当前和未来数量不断增加的啮齿动物笼子进行有效消毒。 RT 目前有两台灭菌器（Amsco 和 Steris）。虽然两者都很低调，但它们都很旧，并且具有显着的可维护性和吞吐量限制。事实上，Amsco 灭菌器几乎处于无法运行的状态，必须立即更换。此外，现有的消毒机都无法对架子进行消毒。如果没有所需的设备，RU 首席研究员 (PI) 将继续面临维持现有屏障啮齿动物群落或扩大这些群落以满足未来需求的挑战。 NIH 资助的 RT-ACF 动物研究将受到重大影响。拟议的新型灭菌器的容量是现有 Amsco 灭菌器的三倍以上，并且与现有型号相比，啮齿动物架、笼子和相关设备的灭菌速度将显着加快。这种新型灭菌器的位置还使其具有双重用途，可以在从脏笼清洗侧装载时对脏架子进行净化，同时在从清洁笼清洗侧使用时对干净架子进行灭菌。更换现有的 Amsco 灭菌器还将使我们能够扭转脏笼清洗和清洁笼清洗的问题，以改善交通流量并增强生物安全。购买所需的架/笼式灭菌器同样可以节省更多的环境资源。尽管附近公共卫生学院大楼 (SPH) 的 ACF 拥有大型灭菌器、后勤距离、生物安全性等，更重要的是，SPH-ACF 的灭菌负荷过大，导致 RT-ACF 无法将笼子发送到 SPH-ACF 进行常规灭菌。用新的散装灭菌器替换 RT-ACF 中过时的、功能较差的设备将大大增强 ORAd 支持当前 NIH 资助的罗伯特伍德约翰逊医学院 (RWJMS) 研究人员的能力，并最终允许将药学院 (SOP) 和生物医学工程 (BME) 的 PI 合并到 RT-ACF。减少卫星 ACF 的数量将大大降低 ORAd 的运营成本，并减轻 PI 和 NIH 的每日负担。该设备加上 2587 平方英尺 (SF) 的空间和支持基础设施升级，适合现有设施尺寸，并利用大部分现有基础设施。为了确保设备运行，罗格斯大学将支付除本补助金要求之外的任何额外支出。如果短期内没有新的批量灭菌器，RT-ACF 可能无法满足 RU PI 的啮齿动物需求，因此他们无法正确开展 NIH 资助的研究。