权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

National Particle Therapy Research Center (NPTRC)

国家粒子治疗研究中心（NPTRC）

基本信息

批准号：
9012032
负责人：
HAK CHOY
金额：
$ 50.37万
依托单位：
UT SOUTHWESTERN MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-02-10 至 2018-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9012032
关键词：
Address Animal Housing Biological Cell Nucleus Charge Clinical Clinical Trials Cloud Computing Collaborations Costs and Benefits Cyclotrons Development Dose Education and Outreach Electrons Foundations Funding Goals Grant Heavy Ions Housing Human Individual Letters Linear Accelerator Radiotherapy Systems Medical Medical center Modality Monte Carlo Method Normal tissue morphology Patient Care Peer Review Phase Photons Physics Pilot Projects Positioning Attribute Process Protons Radiation therapy Radiobiology Research Research Activity Research Infrastructure Research Personnel Research Project Grants Resources Secure Solid Structure Supervision Technology Texas Therapeutic Studies Training Tumor Tissue Universities Vendor Vision Work base cancer care cancer radiation therapy design economic cost efficacy testing novel particle particle beam particle therapy pre-clinical proton therapy public health relevance research and development response socioeconomics treatment center working group

项目摘要

DESCRIPTION (provided by applicant): Particle beam radiation therapy (PBRT) has identified strengths compared conventional electron or photon radiation therapy, particularly the favorable depth dose distributions. However, there are still numerous open questions and concerns that should be addressed before it is fully implemented in cancer care. Substantial pre-clinical, clinical, physics, socio-economic and cost benefit research is needed. The application herein lays out the necessary groundwork for the establishment of the National Particle Therapy Research Center (NPTRC). It will be affiliated with the final phase, i.e., the 12C therapy facility of the Texas Center for Advanced Radiation Therapy (TCART), a new tri-modality treatment center at University of Southwestern Medical Center including a conventional photon radiation therapy facility (funded) with 13 linear accelerator bunkers, a connected proton therapy facility (under construction) housing a Varian Cyclotron with 4 full gantries and one fixed-beam room, and ultimately a heavy ion facility (being planned). With the creation of the NPTRC, researchers from across the nation can use the resources to conduct research organized at the national level: in particle and medical physics aimed at the clinical use of charged particles; in radiobiology to better understand the underlying biological mechanisms of tumor and normal tissue response; and in testing the efficacy of PBRT through human clinical trials. The vision of the NPTRC, and particularly how it integrates with the PBRT facility, requires consideration into the optimal structure, layout, infrastructure, and physical and operating configurations. The main goal of this Planning Grant is to design and plan this national research center (NPTRC) through (1) the identification of the research directions, (2) the development of the research beam line specifications, (3) the recruitment of the relevant expertise needed, (4) the development of research collaborations and consortia, and (5) the development of common platforms for collaborative research. This goal will be achieved by pursuing three specific aims. (1) To develop the specifications of the research beam- line and related infrastructure for the NPTRC research activities (Pilot Project #1). (2) To develop a Monte Carlo simulation platform using novel graphics-processing unit (GPU) and cloud computing technologies for PBRT (Pilot Project #2). (3) To establish the overall research directions and develop the necessary infrastructure to support and manage future research activities (Administrative Core and Pilot Project #1). The successful completion of these specific aims will position the NPTRC to coordinate large-scale research projects related to PBRT, develop outreach and training in the use of PBRT and ultimately provide cutting edge patient care and support through TCART.

描述（由申请人提供）：与传统电子或光子放射治疗相比，粒子束放射治疗（PBRT）具有确定的优势，特别是有利的深度剂量分布。然而，在癌症护理中全面实施之前，仍有许多悬而未决的问题和担忧需要解决。需要进行大量的临床前、临床、物理、社会经济和成本效益研究。本申请为建立国家粒子治疗研究中心（NPTRC）奠定了必要的基础。它将附属于最后阶段，即，德克萨斯州高级放射治疗中心（TCART）的12 C治疗设施，西南大学医学中心的一个新的三模态治疗中心，包括一个传统的光子放射治疗设施（资助），13个线性加速器掩体，一个连接的质子治疗设施，（在建）容纳一个瓦里安回旋加速器与4个完整的机架和一个固定束室，并最终重离子设施（正在规划中）。随着NPTRC的创建，来自全国各地的研究人员可以利用这些资源在国家一级进行研究：在粒子和医学物理学方面，旨在临床使用带电粒子;在放射生物学方面，以更好地了解肿瘤和正常组织反应的潜在生物学机制;并通过人体临床试验测试PBRT的疗效。NPTRC的愿景，特别是它如何与PBRT设施集成，需要考虑最佳结构，布局，基础设施以及物理和操作配置。该规划补助金的主要目标是通过以下方式设计和规划该国家研究中心（NPTRC）：（1）确定研究方向，（2）制定研究光束线规范，（3）招募所需的相关专业知识，（4）发展研究合作和联盟，以及（5）开发合作研究的通用平台。这一目标将通过实现三个具体目标来实现。(1)为NPTRC研究活动（试点项目#1）制定研究光束线和相关基础设施的规格。(2)使用新型图形处理单元（GPU）和云计算技术为PBRT开发蒙特卡罗模拟平台（试点项目#2）。(3)建立整体研究方向，发展必要的基础设施，以支持和管理未来的研究活动（行政核心和试点项目#1）。这些具体目标的成功完成将使NPTRC能够协调与PBRT相关的大型研究项目，开发PBRT使用方面的推广和培训，并最终通过TCART提供尖端的患者护理和支持。