Perinatal stress leads to neurosteroid deficits and adverse behavioural outcomes

这项资助将研究出生后经历的社会心理压力对新生动物大脑中类固醇激素的产生和调节的影响。这项工作将调查压力如何改变这些大脑类固醇的水平和对它们的敏感性，以及这些影响是否会持续到成年期。这些研究将确定这些变化是否会导致青少年行为障碍。类固醇疗法治疗这些疾病的有效性也将被确定。

This grant will examine the effect of psychosocial stress experienced after birth on the production and regulation of steroid hormones in the brain of newborn animals. The work will investigate how stress changes the levels these brain steroids and sensitivity to them and if these effects are remain into adulthood. The studies will then determine if these changes lead to adolescent behaviour disorders. The effectiveness of steroid therapies in treating these disorders will also be determined.