Perinatal stress leads to neurosteroid deficits and adverse behavioural outcomes

围产期压力导致神经类固醇缺陷和不良行为结果

• 批准号: nhmrc : 1079834
• 负责人: Dr Hannah Palliser
• 金额: $ 79.89万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/perinatal-stress-leads-behavioural-outcomes/518703
• 关键词: Perinatal; stress; leads; neurosteroid; deficits

This grant will examine the effect of psychosocial stress experienced after birth on the production and regulation of steroid hormones in the brain of newborn animals. The work will investigate how stress changes the levels these brain steroids and sensitivity to them and if these effects are remain into adulthood. The studies will then determine if these changes lead to adolescent behaviour disorders. The effectiveness of steroid therapies in treating these disorders will also be determined.

这项资助将研究出生后经历的心理社会压力对新生动物大脑中类固醇激素的产生和调节的影响。这项工作将研究压力如何改变这些大脑类固醇的水平和对它们的敏感性，以及这些影响是否会持续到成年。这些研究将确定这些变化是否会导致青少年行为障碍。类固醇治疗在治疗这些疾病的有效性也将被确定。