Peripheral neuropathy and pain: Role of the sphingosine kinase-sphingosine 1-phosphate system

周围神经病变和疼痛：鞘氨醇激酶 - 1-磷酸鞘氨醇系统的作用

• 批准号: nhmrc : 535055
• 负责人: A/Pr Michael Michael
• 金额: $ 18.86万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/peripheral-neuropathy-pain-1-phosphate/98949
• 关键词: Peripheral; neuropathy; pain; Role; sphingosine

Understanding the neural mechanisms that generate pathological pain remains one of the essential goals for the development of effective treatments for pain, chronic pain with less side effects. Lipids are able to modulate pain perception. We will determine the role of a molecule named sphingosine 1-phosphate as a basis for the development of therapies for the treatment of neuropathic pain.

了解产生病理性疼痛的神经机制仍然是开发有效治疗疼痛、慢性疼痛且副作用较少的重要目标之一。脂质能够调节疼痛感知。我们将确定一种名为1-磷酸鞘氨醇的分子的作用，作为开发神经性疼痛治疗方法的基础。