Mechanisms of Resistance to Immunological Targeting of Primary and Metastatic Colorectal Cancers

原发性和转移性结直肠癌免疫靶向的耐药机制

• 批准号: nhmrc : 1140147
• 负责人: A/Pr Michael Michael
• 金额: $ 41.44万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-resistance-immunological-colorectal-cancers/1319173
• 关键词: Mechanisms; Resistance; Immunological; Targeting; Primary

The immune system influences the outcome in patients with cancer. We have been early adopters of immunotherapy approaches to target cancer cells using the novel approaches to enhance immune attack on cells that aberrantly express cancer regulators. These represent drivers to which cancer cells are addicted. A central tenant of optimizing immunotherapies has been to employ immune stimuli in concert with removing immune blocking systems. Our research plan is to improve immunotherapy efficiency.

免疫系统影响癌症患者的预后。我们是早期采用免疫治疗方法来靶向癌细胞的人，使用新方法来增强对异常表达癌症调节因子的细胞的免疫攻击。这些代表了癌细胞上瘾的驱动因素。优化免疫疗法的一个核心租户是采用免疫刺激与消除免疫阻断系统。我们的研究计划是提高免疫治疗的效率。