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Mechanisms of Resistance to Immunological Targeting of Primary and Metastatic Colorectal Cancers

Mechanisms of Resistance to Immunological Targeting of Primary and Metastatic Colorectal Cancers
原发性和转移性结直肠癌免疫靶向的耐药机制
批准号:
nhmrc : 1140147
负责人:
A/Pr Michael Michael
金额:
$41.44万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 2021-12-31

项目摘要

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中文摘要
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英文摘要
The immune system influences the outcome in patients with cancer. We have been early adopters of immunotherapy approaches to target cancer cells using the novel approaches to enhance immune attack on cells that aberrantly express cancer regulators. These represent drivers to which cancer cells are addicted. A central tenant of optimizing immunotherapies has been to employ immune stimuli in concert with removing immune blocking systems. Our research plan is to improve immunotherapy efficiency.
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会议论文
A randomised phase III trial of preoperative chemoradiotherapy vs preoperative chemotherapy for resectable gastric cancer
  • 批准号:
    nhmrc : 1046425
  • 项目类别:
    Project Grants
  • 资助金额:
    $138.3万
  • 财政年份:
    2013
  • 负责人:
    A/Pr Michael Michael
  • 依托单位:
The TOPGEAR trial; trial of preoperative therapy for gastric and esophagogastric junction adenocarcinoma
  • 批准号:
    nhmrc : GNT1046425
  • 项目类别:
    Project Grants
  • 资助金额:
    $197.46万
  • 财政年份:
    2013
  • 负责人:
    A/Pr Michael Michael
  • 依托单位:
Evaluation of blood-based screening tests for colorectal neoplasia; from biomarker candidates to accurate and acceptable tests
  • 批准号:
    nhmrc : 1006242
  • 项目类别:
    Project Grants
  • 资助金额:
    $51.17万
  • 财政年份:
    2011
  • 负责人:
    A/Pr Michael Michael
  • 依托单位:
Development of a blood-based screening test for colorectal neoplasia; biomarker expression in circulating tumor cells and tumor-derived microvesicles
  • 批准号:
    nhmrc : 1017083
  • 项目类别:
    Development Grants
  • 资助金额:
    $34.27万
  • 财政年份:
    2011
  • 负责人:
    A/Pr Michael Michael
  • 依托单位:
国内基金
海外基金
Naringin通过改善Leptin Resistance调节肠上皮AQP3重建糖脂代谢平衡的机制研究
  • 批准号:
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2025
  • 负责人:
    周烨
  • 依托单位:
E-cadherin调控卵巢癌细胞anoikis-resistance的分子机制及干预
  • 批准号:
    81172487
  • 项目类别:
    面上项目
  • 资助金额:
    60.0万元
  • 批准年份:
    2011
  • 负责人:
    刘联
  • 依托单位: