MICRORNA PREDICTORS OF OESOPHAGEAL TUMOUR RESPONSE TO CHEMOTHERAPY AND RADIOTHERAPY

食管肿瘤对化疗和放疗反应的微小RNA预测因子

• 批准号: nhmrc : 595964
• 负责人: A/Pr Michael Michael
• 金额: $ 44.01万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/microrna-predictors-oesophageal-chemotherapy-radiotherapy/77814
• 关键词: MICRORNA; PREDICTORS; OESOPHAGEAL; TUMOUR; RESPONSE

Chemoradiotherapy (CRT) is used for the treatment of oesophageal cancer before surgical resection, and for patients not undergoing surgery. However, it is unsuccessful for many, causing side effects, no clinical gain, and delaying surgery. MicroRNAs are small molecules that control cellular functions. This project will identify miRNA markers which are able to predict cancer response to CRT, and this will help clinical decision making for individualized treatment.

放化疗（CRT）用于手术切除前的食管癌治疗，以及未接受手术的患者。然而，对于许多人来说，这是不成功的，会引起副作用，没有临床收益，并推迟手术。MicroRNA是控制细胞功能的小分子。该项目将确定能够预测癌症对CRT反应的miRNA标记物，这将有助于临床决策个体化治疗。