Personalized clinical genomics and epigenomics.

导致乳腺癌和前列腺癌风险的遗传因素在很大程度上是未知的。目前已知与易感性相关的基因突变只占这些癌症家族聚集的一小部分。我将把新的基因技术应用于以人群为基础的癌症研究，以确定新的癌症风险的遗传和表观遗传标记。我将利用这些信息来改善前列腺癌和乳腺癌患者家庭的医疗保健。

Genetic factors responsible for risk of breast and prostate cancer are largely unknown. Mutations in genes currently known to be associated with susceptibility only account for a small proportion of the familial aggregation of these cancers. I will be applying new genetic technology to population-based studies of cancer to identify new genetic and epigenetic markers of cancer risk. I will use this information to improve health care for families with prostate and breast cancer.