Pharmacogenomics of renal transplantation

肾移植的药物基因组学

• 批准号: nhmrc : 565038
• 负责人: A/Pr Benedetta Sallustio
• 金额: $ 23.89万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/pharmacogenomics-renal-transplantation/100520
• 关键词: Pharmacogenomics; renal; transplantation

Kidney transplantation is the only cure for end-stage kidney disease. Although drugs are used to prevent rejection of the new kidney, there is significant inter-individual variability in patients' repsonse. Many factors are involved including age, other diseases and use of other drugs. Individual's genetic make up may also contribute to this variability. This study will show how variability in genes that control drug transport and action affect the risk of rejection and long-term kidney function.

肾移植是治疗终末期肾病的唯一方法。虽然药物被用来防止新肾的排斥反应，但患者的反应存在显著的个体差异。许多因素包括年龄、其他疾病和使用其他药物。个体的遗传组成也可能导致这种变异性。这项研究将显示控制药物转运和作用的基因的变异性如何影响排斥反应和长期肾功能的风险。