Pharmacogenomics of renal transplantation

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Kidney transplantation is the only cure for end-stage kidney disease. Although drugs are used to prevent rejection of the new kidney, there is significant inter-individual variability in patients' repsonse. Many factors are involved including age, other diseases and use of other drugs. Individual's genetic make up may also contribute to this variability. This study will show how variability in genes that control drug transport and action affect the risk of rejection and long-term kidney function.