Carbohydrate language changes in vertebrate-pathogen co-evolution

该项目旨在了解蛋白质糖基化在宿主-病原体关系和跨物种传播中的作用。物种特异性糖广泛修饰细胞表面和体液蛋白。这些聚糖构建了细胞使用和病原体滥用的通用语言。该项目将使用糖组学和糖蛋白组学来揭示病原体如何学习说话和解释不同物种之间的糖语言。该项目有望开发一个聚糖字典，揭示脊索动物门中宿主-病原体的协同进化和糖基化进化，抵御人畜共患病的威胁。

This project aims to understand protein glycosylation’s role in host-pathogen relationships and cross-species transmission. Species specific sugars extensively modify cell surface and body fluid proteins. These glycans build a universal language that cells use and pathogens abuse. This project will use glycomics and glycoproteomics to uncover how pathogens learned to speak and interpret glyco-languages between different species. This project is expected to develop a glycan dictionary which could reveal host-pathogen co-evolution and glycosylation evolution in the Chordata phylum and counteract zoonoses threats.