POISE-2: A large, international, placebo-controlled, factorial trial to assess the impact of clonidine and aspirin in patients undergoing noncardiac surgery who are at risk of a perioperative cardiovascular event

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At least 5 million patients annually worldwide suffer a heart attack or die after noncardiac surgery. Despite the magnitude of this problem, there are no good treatments to prevent these complications. Previous studies suggest that the drugs clonidine and aspirin may minimize the risk of heart attack after surgery. The POISE-2 trial will study 10,000 patients having noncardiac surgery to determine if clonidine and aspirin improve outcomes. This trial will influence the treatment of patients having surgery around the world.