Polyunsaturated fatty acids mimetics with anti-inflammatory properties

自身免疫性疾病是导致我们社区高发病率和死亡率的原因。免疫抑制药物-抗炎药在治疗这些疾病以及帮助防止移植组织-器官排斥反应方面发挥了重要作用。医学界正在不断寻找更好的免疫抑制药物和制剂用于这些目的。根据过去几年进行的研究，我们已经部分确定了多不饱和脂肪酸(PUFA)上负责特定生物功能的结构元件。利用这些信息，我们已经合成了一大批以前没有的多不饱和脂肪酸，我们可以用它们来靶向T淋巴细胞，并驱动这些化合物的生物活性，优先走向免疫抑制。通过开展这一项目中概述的研究，我们可能要么确定一种先导免疫抑制化合物，要么为进一步合成以多不饱和脂肪酸为基础的化合物提供新的信息，以便进一步研究作为潜在的免疫抑制剂。

Autoimmune diseases are responsible for a high incidence of morbidity and mortality in our community. Immunosuppressive drugs-anti-inflammatory agents have played important roles in treatment of these diseases as well as in helping to prevent rejection of transplanted tissues-organs. There is an ongoing search by the medical community for better immunosuppressive drugs and agents for use for these purposes. Based on studies conducted in the last few years, we have partially identified structural elements on polyunsatrated fatty acids (PUFA) which are responsible for specific biological functions. Using this information, we have synthesized a large panel of previously unavailable PUFA which we can use to target T lymphocytes and drive the biological activity of these compounds, preferentially towards immunosuppression. By conducting the research outlined in this project, we are likely to either identify a lead immunosuppressive compound or generate new information for further synthesis of PUFA-based compounds for further examination as potential immunosuppressive agents.