Postprandial Lipid Metabolism in Familial Hypercholersterolaemia: Mechanisms and Effects of Omega-3 Fatty Acid Ethyl Esters

家族性高胆固醇血症的餐后脂质代谢：Omega-3 脂肪酸乙酯的机制和作用

• 批准号: nhmrc : 1028883
• 负责人: A/Pr David Sullivan
• 金额: $ 41.1万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/postprandial-lipid-metabolism-ethyl-esters/110667
• 关键词: Postprandial; Lipid; Metabolism; Familial; Hypercholersterolaemia

Familial hypercholesterolaemia (FH) is the most common genetic condition known to cause premature coronary heart diseaseis (CHD). The increasd CHD risk in FH may be in part due to accumulation of fat in blood. Fish oil supplementation may be a new target, additional to standard best therapy, for reducing CHD risk in FH. Our results will add value to the science behind and clinical therapy for lipid disorders in FH, and will establish a key role for fish oils.

家族性高胆固醇血症（FH）是引起早发冠心病（CHD）最常见的遗传性疾病。FH中CHD风险增加的部分原因可能是血液中脂肪的积聚。鱼油补充剂可能是一个新的目标，除了标准的最佳治疗，以减少FH的CHD风险。我们的研究结果将为FH中脂质紊乱的科学和临床治疗增加价值，并将确立鱼油的关键作用。