Prediction of adverse outcomes following a fragility fracture

患有现有骨折的人面临着更高的不良后果风险，如再次骨折和过早死亡，但原因尚不清楚。我们建议评估风险因素和预后模型，以预测不良结局的风险。我们还建议开发一个量化的风险-收益框架来评估这种预后模型的临床实用性，并帮助确保治疗适当地解决骨质疏松症患者的现实生活经验。

Individuals with an existing fracture are at increased risk of adverse outcomes such as re-fracture and premature mortality, but it is not clear why. We propose to evaluate risk factors, and prognostic models, for predicting the risk of adverse outcomes. We also propose to develop a quantitative risk-benefit framework for evaluating the clinical utility of such prognostic models and help ensure that therapies appropriately address real-life experience of osteoporotic patients.