Preventing Adverse Effects of Matrix Metalloproteinases in Diabetic Wound Healing

预防基质金属蛋白酶对糖尿病伤口愈合的不利影响

• 批准号: nhmrc : 1009815
• 负责人: A/Pr Susan Mclennan
• 金额: $ 25.86万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/preventing-adverse-effects-wound-healing/109430
• 关键词: Preventing; Adverse; Effects; Matrix; Metalloproteinases

Treatment of diabetic foot ulcers presents a significant challenge to diabetic patients and the health care system. Despite concerted treatment, many ulcers do not heal and it is this failure to heal which eventually leads to deep-seated infection and amputation. For these reasons development of new therapeutic strategies to improve wound healing in diabetes is of critical importance. In this study we investigate the role of MMPs in particular MMP-9 in diabetic wounds and examine whether MMP inhibition will improve wound healing in diabetes.

糖尿病足溃疡的治疗对糖尿病患者和医疗保健系统提出了重大挑战。尽管协调一致的治疗，许多溃疡不愈合，这是这种未能愈合，最终导致深层感染和截肢。由于这些原因，开发新的治疗策略以改善糖尿病伤口愈合至关重要。在这项研究中，我们研究了MMP-9在糖尿病伤口中的作用，并研究了MMP抑制是否会改善糖尿病伤口愈合。