Diabetes exacerbates non-alcoholic steato-hepatitis (NASH)

糖尿病会加剧非酒精性脂肪性肝炎 (NASH)

• 批准号: nhmrc : 632822
• 负责人: A/Pr Susan Mclennan
• 金额: $ 37.72万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/diabetes-exacerbates-non-hepatitis-nash/82282
• 关键词: Diabetes; exacerbates; non; alcoholic; steato

Non-alcoholic steato-hepatitis (NASH) is a common disease of liver inflammation and scarring, which may progress to cirrhosis or liver cancer. While type 2 diabetes causes a higher rate of NASH and more rapid NASH progression the reasons for this are not clear. We have developed a novel animal model of NASH with diabetes added to dietary induced obesity. We show that a growth factor is elevated in the affected livers. We plan to block the growth factor to see if we can prevent NASH worsening.

非酒精性脂肪性肝炎(NASH)是一种常见的肝脏炎症和瘢痕形成疾病，可发展为肝硬变或肝癌。虽然2型糖尿病导致更高的NASH发生率和更快的NASH进展，但其原因尚不清楚。我们开发了一种新的NASH动物模型，并在饮食诱导肥胖的基础上增加了糖尿病。我们发现，受影响的肝脏中有一种生长因子升高。我们计划阻断增长因素，看看能否防止纳什恶化。