Role of Inflammation in Diabetic Cardiomyopathy

炎症在糖尿病心肌病中的作用

• 批准号: nhmrc : 1030376
• 负责人: A/Pr Susan Mclennan
• 金额: $ 32.88万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-inflammation-diabetic-cardiomyopathy/110751
• 关键词: Role; Inflammation; Diabetic; Cardiomyopathy

Diabetic cardiomyopathy (DiabCM) is common in people with diabetes. It predisposes to heat failure. Its cause remains unclear and there is no specific treatment for DiabCM. Inflammation is a fundamental tissue response to a metabolic insult and it occur in DiabCM. The central hypothesis in this work is that inflammation through myocardial macrophage cells contributes to DiabCM. This hypothesis will be tested in animal models and also in cell culutre studies.

糖尿病心肌病(DiabCM)在糖尿病患者中很常见。它容易发生热故障。其病因尚不清楚，目前尚无治疗糖尿病的特效药。炎症是组织对代谢损伤的一种基本反应，它发生在糖尿病患者身上。这项工作的中心假设是通过心肌巨噬细胞的炎症有助于糖尿病的发生。这一假设将在动物模型和细胞培养研究中得到验证。