THE ROLE OF THE HEPATOCYTE IN EXTRACELLULAR MATRIX INTERACTIONS IN LIVER FIBROGENESIS

肝细胞在肝纤维生成中细胞外基质相互作用中的作用

• 批准号: nhmrc : 512283
• 负责人: A/Pr Susan Mclennan
• 金额: $ 36.04万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-hepatocyte-extracellular-liver-fibrogenesis/76173
• 关键词: ROLE; HEPATOCYTE; EXTRACELLULAR; MATRIX; INTERACTIONS

This study focuses on the main cell within the liver, the hepatocyte, and its role in the development of liver fibrosis. Liver fibrosis arising from liver injury has a common progression characterised by loss of liver structure and the development of dense fibrous bands of tissue in the condition known as cirrhosis. The importance of the outlined research plan is that for the first time the hepatocyte has been identified as having a significant role in the development of liver fibrosis.

本研究着重于肝脏内的主要细胞，肝细胞，及其在肝纤维化发展中的作用。由肝损伤引起的肝纤维化具有共同的进展，其特征在于肝结构的丧失和在称为肝硬化的病症中的组织的致密纤维带的发展。概述的研究计划的重要性在于，肝细胞首次被确定为在肝纤维化的发展中具有重要作用。