Proatherogenic CD4 NKT cells and atherosclerosis: molecular mechanisms and therapeutic strategies for suppression

促动脉粥样硬化 CD4 NKT 细胞和动脉粥样硬化：分子机制和抑制治疗策略

• 批准号: nhmrc : 1030515
• 负责人: A/Pr Peter Tipping
• 金额: $ 33.63万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/proatherogenic-cd4-nkt-strategies-suppression/110760
• 关键词: Proatherogenic; CD4; NKT; cells; atherosclerosis

Immune cells called CD4+ iNKT cells are known to be activated by lipids which initiate development of atherosclerosis, a disorder of blood vessels which is responsible for most heart attacks and strokes. We aim to investigate how these cells contribute to the development of this important blood vessel disoder and examine potential ways of inhibiting their activation to prevent heart attacks and strokes.

已知称为CD4+ iNKT细胞的免疫细胞被脂质激活，脂质启动动脉粥样硬化的发展，动脉粥样硬化是一种血管疾病，是大多数心脏病发作和中风的原因。我们的目标是研究这些细胞如何促进这种重要的血管疾病的发展，并研究抑制其激活以预防心脏病发作和中风的潜在方法。