Regulatory T cells and Cardiac Fibrosis in Hypertensive Heart Disease: Cellular and Molecular Mechanisms of Suppression

高血压性心脏病中的调节性 T 细胞和心脏纤维化：抑制的细胞和分子机制

• 批准号: nhmrc : 1049356
• 负责人: A/Pr Peter Tipping
• 金额: $ 47.7万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulatory-t-cells-mechanisms-suppression/112076
• 关键词: Regulatory; cells; Cardiac; Fibrosis; Hypertensive

Excessive accumulation of collagen in the heart, cardiac fibrosis is a major factor causing heart failure and sudden death. How collagen accumulation occurs in the heart still needs to be elucidated but recent studies in humans and animal models of cardiac fibrosis indicate a significant role for inflammation. The proposed studies are to address this issue and how to regulate inflammation in the heart to suppress cardiac fibrosis, using immune cells called regulatory T cells that suppress inflammation.

胶原蛋白在心脏内过度堆积，心脏纤维化是引起心力衰竭和猝死的主要因素。胶原蛋白在心脏中是如何积聚的仍需阐明，但最近对人类和心脏纤维化动物模型的研究表明炎症的重要作用。拟议的研究是为了解决这个问题，以及如何调节心脏炎症以抑制心脏纤维化，使用称为抑制炎症的调节性T细胞的免疫细胞。