Natural Killer (NK) Cells and Development of Atherosclerosis: Cellular and Molecular Mechanisms

自然杀伤 (NK) 细胞与动脉粥样硬化的发展：细胞和分子机制

• 批准号: nhmrc : 1068500
• 负责人: A/Pr Peter Tipping
• 金额: $ 48.65万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/natural-killer-nk-molecular-mechanisms/455348
• 关键词: Natural; Killer; NK; Cells; Development

Atherosclerosis, the accumulation of fat and white cells in the blood vessel wall is the major cause of heart attacks, stroke and death. Cholesterol lowering drugs reduce the risk by only 40%. Targeting cells that promote inflammation is one approach to further reduce risk. We have shown that a specific cell type called a natural killer (NK) cells contributes greatly to development of atherosclerosis. Our aim is to understand how these cells promote development of atherosclerosis.

动脉粥样硬化，脂肪和白色细胞在血管壁的积累是心脏病发作，中风和死亡的主要原因。降低胆固醇的药物只能降低40%的风险。靶向促进炎症的细胞是进一步降低风险的一种方法。我们已经证明，一种称为自然杀伤（NK）细胞的特定细胞类型对动脉粥样硬化的发展有很大的贡献。我们的目的是了解这些细胞如何促进动脉粥样硬化的发展。