Atherosclerosis: Molecular action and suppression of NKT cell subsets

动脉粥样硬化：NKT 细胞亚群的分子作用和抑制

• 批准号: nhmrc : 436854
• 负责人: A/Pr Peter Tipping
• 金额: $ 30.59万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/atherosclerosis-molecular-action-cell-subsets/76183
• 关键词: Atherosclerosis; Molecular; action; suppression; NKT

Atherosclerosis, or hardening of large arteries, is the underlying cause of up to 50% of deaths in Western communities from heart attacks and strokes. Today it is considered a chronic inflammatory disease arising from the influx of fats such as cholesterol into the inner liming of arteries that provide blood supply to organs such as the heart and the brain. However, the exact role that inflammation plays in the development of this blood vessel disease is poorly understood. This study is directed towards understanding the role of a subset of while blood cells known as NKT cells in the inflammatory process. In particular we will examine whether the activity of NKT cells in promoting atherosclerosis can be controlled either by the administration of drugs that deprive them of molecules that stimulate their activity and-or by the injection of another population of white blood cells known as regulatory T cells that may to limit their activity. Our preclinical study of atherosclerosis in mice has potential for extension to the control of atherosclerosis in humans. Successful translation in this way can be expected to provide a significant health benefit.

动脉粥样硬化或大动脉硬化是西方社区高达50%的心脏病发作和中风死亡的根本原因。今天，它被认为是一种慢性炎症性疾病，由脂肪如胆固醇流入动脉内膜引起，动脉为心脏和大脑等器官提供血液供应。然而，炎症在这种血管疾病发展中的确切作用尚不清楚。这项研究旨在了解称为NKT细胞的白细胞亚群在炎症过程中的作用。特别是，我们将研究NKT细胞促进动脉粥样硬化的活性是否可以通过给予药物来控制，使其失去刺激其活性的分子，或者通过注射另一群被称为调节性T细胞的白色血细胞来限制其活性。我们在小鼠动脉粥样硬化的临床前研究有可能扩展到人类动脉粥样硬化的控制。以这种方式成功的翻译可以预期提供显着的健康益处。