Promoting regrowth of nerve fibres into the epidermis during diabetic neuropathy by LRP agonists

LRP 激动剂促进糖尿病神经病变期间神经纤维再生至表皮

• 批准号: nhmrc : 1088952
• 负责人: A/Pr Lisa Foa
• 金额: $ 28.48万
• 依托单位: Antarctic Climate and Ecosystems CRC, University of Tasmania
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/promoting-regrowth-nerve-lrp-agonists/519239
• 关键词: Promoting; regrowth; nerve; fibres; into

Nerve damage can develop post injury or disease and is often very debilitating, slow to heal and can cause increased pain. Our work aims to examine a new class of molecules that we show can activate selected fat-receptors on nerve cells to guide the growth of regenerating nerves. We will determine how these receptors function with the aim of developing a novel class of therapeutics directed at healing nerve damage.

神经损伤可以在受伤或疾病后发展，通常非常虚弱，愈合缓慢，并可能导致疼痛加剧。我们的工作旨在研究一类新的分子，我们发现它们可以激活神经细胞上选定的脂肪受体，以指导再生神经的生长。我们将确定这些受体如何发挥作用，目的是开发一类新的治疗方法，用于治疗神经损伤。