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Promoting regrowth of nerve fibres into the epidermis during diabetic neuropathy by LRP agonists

Promoting regrowth of nerve fibres into the epidermis during diabetic neuropathy by LRP agonists
LRP 激动剂促进糖尿病神经病变期间神经纤维再生至表皮
批准号:
nhmrc : 1088952
负责人:
A/Pr Lisa Foa
金额:
$28.48万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 2018-12-31

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中文摘要
翻译
神经损伤可以在受伤或疾病后发展,通常非常虚弱,愈合缓慢,可能导致疼痛增加。我们的工作旨在研究一类新的分子,我们展示了这种分子可以激活神经细胞上选定的脂肪受体,以指导再生神经的生长。我们将确定这些受体是如何发挥作用的,目的是开发一种新的治疗方法,旨在修复神经损伤。
英文摘要
Nerve damage can develop post injury or disease and is often very debilitating, slow to heal and can cause increased pain. Our work aims to examine a new class of molecules that we show can activate selected fat-receptors on nerve cells to guide the growth of regenerating nerves. We will determine how these receptors function with the aim of developing a novel class of therapeutics directed at healing nerve damage.
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会议论文
Neuron to glia signalling: learning how synaptic signalling can promote CNS remyelination
Deciphering the mechanisms underlying LRP-mediated axon guidance
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