Neuron to glia signalling: learning how synaptic signalling can promote CNS remyelination

大脑中一种未成熟的细胞类型，被称为少突胶质细胞祖细胞（OPC），接受来自神经元的直接电通信。这种交流调节OPC的行为，影响其分裂和产生新脑细胞的能力。这个项目将确定信号分子，引导OPC与神经细胞进行这种特殊的接触。了解这种交流对多发性硬化症的治疗具有重要意义。

An immature cell type in the brain, known as the oligodendrocytes progenitor cell (OPC), receives direct electrical communication from neurons. This communication regulates the behavior of the OPC, affecting its ability to divide and generate new brain cells. This project will identify the signaling molecules that guide the OPC to for this specialized contact with the nerve cell. Understanding this communication has important implications for the treatment of Multiple Sclerosis.