Neuron to glia signalling: learning how synaptic signalling can promote CNS remyelination

神经元到神经胶质信号传导：了解突触信号传导如何促进中枢神经系统髓鞘再生

• 批准号: nhmrc : 1066025
• 负责人: A/Pr Lisa Foa
• 金额: $ 40.65万
• 依托单位: Antarctic Climate and Ecosystems CRC, University of Tasmania
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/neuron-glia-signalling-cns-remyelination/455216
• 关键词: Neuron; glia; signalling; learning; how

An immature cell type in the brain, known as the oligodendrocytes progenitor cell (OPC), receives direct electrical communication from neurons. This communication regulates the behavior of the OPC, affecting its ability to divide and generate new brain cells. This project will identify the signaling molecules that guide the OPC to for this specialized contact with the nerve cell. Understanding this communication has important implications for the treatment of Multiple Sclerosis.

大脑中的一种未成熟细胞类型，称为少突胶质细胞前体细胞(OPC)，接受神经元的直接电通讯。这种交流调节OPC的行为，影响其分裂和产生新脑细胞的能力。这个项目将确定引导OPC与神经细胞进行这种专门接触的信号分子。了解这种交流对于多发性硬化症的治疗具有重要的意义。